The hepatic biosynthesis of rat thyroxine binding globulin (TBG): demonstration, ontogenesis, and up-regulation in experimental hypothyroidism

Biochemical and Biophysical Research Communications
R VranckxI L Flink

Abstract

Using a human thyroxine binding globulin (TBG) cDNA probe, we demonstrate that rat liver contains two TBG mRNA species of different length, consisting of about 1.8 Kb and 2.4 Kb respectively. Slot blot analysis of the hepatic mRNAs from rats of different age reveals a fair correlation between the developmental trend of the messengers and that of the TBG circulating levels. Finally Northern blot and slot studies demonstrate that the increase of serum TBG induced in adults by thyroidectomy actually reflects an enhanced hepatic biosynthesis of the protein.

References

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Citations

Dec 1, 1993·Molecular and Cellular Endocrinology·A Tsykin, G Schreiber
Jul 26, 1991·Biochimica Et Biophysica Acta·L SavuI L Flink
Aug 30, 2001·Thyroid : Official Journal of the American Thyroid Association·L H DuntasD A Koutras
Jan 30, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Joana Almeida Palha
Jan 17, 2012·Proteomics·Elisabetta GianazzaIngrid Miller
Nov 23, 2006·Annals of the New York Academy of Sciences·R Thomas Zoeller
Jun 14, 2008·Molecular and Cellular Endocrinology·Samantha J Richardson
Oct 10, 2009·International Journal of Toxicology·J M HedgeK M Crofton
Mar 16, 2000·Thyroid : Official Journal of the American Thyroid Association·G C Schussler
Nov 5, 2019·Frontiers in Neurology·Daniela TalhadaKarsten Ruscher
May 1, 1993·Journal of Endocrinological Investigation·L Bartalena
Jan 15, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Samantha J RichardsonMarilyn B Renfree
Aug 24, 2019·Frontiers in Endocrinology·Sarah A RabahSamantha J Richardson

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