The hepatic glutathione content in liver diseases

Scandinavian Journal of Clinical and Laboratory Investigation
H E PoulsenP B Andreasen

Abstract

We measured the total glutathione content in 38 liver biopsies from patients undergoing diagnostic liver biopsy to study whether liver diseases result in decreased glutathione content making the liver more sensitive to different toxic damages. The glutathione concentrations ranged from 20.2 to 41.0 mumol/g hepatic protein in six biopsies without light microscopic pathological changes (mean +/- SD = 26.9 = +/- 8.1). The mean concentrations +/- SD in patients with toxic hepatitis (n = 3), viral hepatitis (n = 4), chronic active hepatitis (n = 4), cirrhosis (n = 14) and steatosis (n = 7) were 62.5 +/- 27.2, 47.4 +/- 25.9, 38.3 +/- 17.0, 29.1 +/- 15.7 and 21.0 +/- 9.6, respectively. The hepatic glutathione content is not decreased in patients with moderate hepatic impairment.

References

Jul 1, 1979·European Journal of Clinical Pharmacology·J A ForrestL F Prescott
Apr 6, 1973·Science·A Meister
Oct 1, 1974·Clinical Pharmacology and Therapeutics·J R MitchellH Keiser
Jan 1, 1980·Pharmacology·M MilandriP B Andreasen

❮ Previous
Next ❯

Citations

Jan 1, 1984·Journal of Cancer Research and Clinical Oncology·C P SiegersM Younes
Feb 15, 1984·Klinische Wochenschrift·R HoppenkampsC P Siegers
Jan 1, 1995·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·E PuruckerG Krandik
Nov 14, 1983·The American Journal of Medicine·G D Benson
Nov 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S LoftH Sørensen
Aug 23, 2001·Pharmacology & Therapeutics·A Bomzon, P Ljubuncic
Mar 1, 1997·Journal of Hepatology·G BianchiG Marchesini
Mar 16, 2005·American Journal of Therapeutics·Gordon D BensonKeith G Tolman
Jan 1, 1992·Journal of Gastroenterology and Hepatology·T ShigesawaF Marumo
Aug 13, 2002·American Journal of Veterinary Research·Sharon A CenterHollis N Erb
Jan 8, 1999·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·E PuruckerS Matern
Nov 25, 2000·Metabolism: Clinical and Experimental·G BianchiG Marchesini
May 1, 1989·Scandinavian Journal of Gastroenterology·G VendemialeO Albano
May 7, 2002·Journal of Toxicology. Clinical Toxicology·Barry H Rumack
Feb 15, 2005·Clinical Biochemistry·Piero PortincasaGiuseppe Palasciano
Feb 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M L BoisioM Esposito
Jan 1, 1986·Journal of Hepatology·S A JewellO Albano
May 1, 1992·Scandinavian Journal of Clinical and Laboratory Investigation·C LoguercioG Nardi
Jul 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Barry H Rumack
Oct 1, 1984·Journal of Applied Toxicology : JAT·P Di SimplicioM Lodovici
May 1, 1993·Scandinavian Journal of Gastroenterology·H E PoulsenK Dalhoff
Jun 18, 2019·Journal of Pain & Palliative Care Pharmacotherapy·Anne E Schweighardt, Katherine M Juba
Jul 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L Zieve
Feb 28, 2008·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Simona RossiVictor J Navarro
Aug 26, 2000·The Journal of Nutrition·I GrattaglianoE Altomare
Oct 27, 2017·European Journal of Clinical Pharmacology·Thomas M CaparrottaJames W Dear
Feb 1, 1984·Acta Pharmacologica Et Toxicologica·H E Poulsen, B Korsholm
May 1, 1992·Journal of Hepatology·A YaariZ Ben-Zvi
Jan 1, 1983·Pharmacological Research Communications·C P Siegers, M Younes

❮ Previous
Next ❯

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