PMID: 523972May 1, 1979Paper

The hepatic secretion of lecithin: cholesterol acyltransferase in rats with increased secretion of triglycerides due to ventromedial hypothalamic lesions

Scandinavian Journal of Clinical and Laboratory Investigation
G NordbyK R Norum


Lecithin:cholesterol acyltransferase (LCAT) is postulated to take care of excess cholesterol formed during metabolism of triglyceride (TG)-rich lipoproteins. To test this hypothesis the relationship between secretion of LCAT and TG have been investigated in rats with ventromedial hypothalamic lesions which lead to increased hepatic secretion of TG. 1. The increased plasma concentration of TG in rats with ventromedial hypothalamic lesions was positively correlated to the activity of LCAT in plasma. 2. Incubation of hepatocytes isolated from such rats revealed a positive linear correlation between secretion of TG and of LCAT. 3. The secretion of unesterified cholesterol was neither correlated to the secretion of the acyltransferase nor to the TG.


Oct 21, 1976·Biochimica Et Biophysica Acta·G NordbyK R Norum
Apr 1, 1977·European Journal of Clinical Investigation·P BelfrageT Wiebe
Nov 1, 1975·Scandinavian Journal of Clinical and Laboratory Investigation·L Wallentin, O Vikrot
May 1, 1976·The Journal of Cell Biology·C A AlexanderR J Havel
Jul 30, 1976·European Journal of Clinical Investigation·B J Kudchodkar, H S Sodhi
Oct 21, 1975·Biochimica Et Biophysica Acta·A Lovo, B E Hustvedt
Feb 25, 1972·Biochemical and Biophysical Research Communications·C J. FieldingP E. Fielding
Oct 10, 1973·Biochimica Et Biophysica Acta·T Berg, D Boman
Jan 1, 1973·Advances in Enzyme Regulation·E V JensenE R De Sombre
Mar 1, 1973·European Journal of Clinical Investigation·Y AkanumaN Kuzuya
May 1, 1973·Canadian Journal of Biochemistry·H D FabienY L Marcel
Feb 1, 1971·Scandinavian Journal of Clinical and Laboratory Investigation·K T Stokke, K R Norum
Jan 1, 1971·Nutrition and Metabolism·D J Naismith, N A Khan
Jan 1, 1970·Journal of Theoretical Biology·V N Schumaker, G H Adams
Dec 15, 1970·Biochimica Et Biophysica Acta·J B Simon, J L Boyer
Mar 1, 1971·The American Journal of Physiology·T Osuga, O W Portman


Jan 1, 1979·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·B H Dannevig, K R Norum
Jan 1, 1982·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·B H Dannevig, K R Norum
Jan 1, 1983·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·B H Dannevig, K R Norum

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