The hepatocyte growth factor (HGF)-MET receptor tyrosine kinase signaling pathway: Diverse roles in modulating immune cell functions

Cytokine
Subburaj IlangumaranSheela Ramanathan

Abstract

Hepatocyte growth factor (HGF) signaling via the MET receptor is essential for embryonic development and tissue repair. On the other hand, deregulated MET signaling promotes tumor progression in diverse types of cancers. Even though oncogenic MET signaling remains the major research focus, the HGF-MET axis has also been implicated in diverse aspects of immune cell development and functions. In the presence of other hematopoietic growth factors, HGF promotes the development of erythroid, myeloid and lymphoid lineage cells and thrombocytes. In monocytes and macrophages responding to inflammatory stimuli, induction of autocrine HGF-MET signaling can contribute to tissue repair via stimulating anti-inflammatory cytokine production. HGF-MET signaling can also modulate adaptive immune response by facilitating the migration of Langerhans cells and dendritic cells to draining lymph nodes. However, MET signaling has also been shown to induce tolerogenic dendritic cells in mouse models of graft-versus-host disease and experimental autoimmune encephalomyelitis. HGF-MET axis is also implicated in promoting thymopoiesis and the survival and migration of B lymphocytes. Recent studies have shown that MET signaling induces cardiotropism in act...Continue Reading

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Citations

Mar 22, 2016·Cytokine·Subburaj Ilangumaran, Gerardo Ferbeyre
Feb 13, 2018·Nature Reviews. Clinical Oncology·Kabir A Khan, Robert S Kerbel
Jun 3, 2017·Journal of Cellular Physiology·Domenico MattiucciAntonella Poloni
Jan 18, 2018·Journal of Cellular Physiology·Mayrel Palestino-DominguezMaria Concepcion Gutierrez-Ruiz
Jun 11, 2019·Stem Cells Translational Medicine·Sharad K MittalSunil K Chauhan
Nov 18, 2018·International Journal of Molecular Sciences·Federica PapaccioFloriana Morgillo
Apr 21, 2018·Nature Reviews. Cancer·Paolo M ComoglioCarla Boccaccio
Dec 9, 2020·Technology in Cancer Research & Treatment·Sai LiYupeng Hong
Sep 3, 2019·The American Journal of Pathology·Yan ZhouAlessio Giubellino
Jul 24, 2021·Lung Cancer : Targets and Therapy·Toshio FujinoTetsuya Mitsudomi
Sep 7, 2021·Cell Biology International·Zhan-Sheng ZhangDong Fang

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