PMID: 8583799Oct 1, 1995Paper

The hepatoprotective cytochrome P-450 enzyme inhibitor isolated from the Nigerian medicinal plant Cochlospermum planchonii is a zinc salt

Journal of Ethnopharmacology
R AliyuW T Shier

Abstract

Aqueous extracts of Cochlospermum planchonii Hook.f. (Cochlospermaceae) rhizomes are used by native medical practitioners in northern Nigeria to treat jaundice. An extract prepared by a laboratory adaptation of their method was hepatoprotective in carbon tetrachloride-treated rats (CCl4), and it inhibited cytochrome P-450 enzymes, which constitutes a plausible hepatoprotective mechanism. A crystalline inhibitor (0.3% of dry weight of rhizomes) was isolated using inhibition of two rat cytochrome P-450 enzymes, aminopyrine-N-demethylase and aniline hydroxylase, as bioassays to guide fractionation by solvent partitioning, polyamdie column chromatography, preparative thin layer chromatography and fractional crystallization. The inhibitor was identified as zinc formate by inductively coupled plasma atomic emission spectroscopy, nuclear magnetic resonance spectroscopy and comparison with synthetic material by power X-ray diffraction crystallography. Synthetic and plant-derived zinc formate were equally effective as inhibitors of cytochrome P-450 enzymes and as hepatoprotective agents in carbon tetrachloride-treated rats. Cochlospermum planchonii rhizomes contain unusually high levels of manganese and zinc, although much higher levels...Continue Reading

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Citations

Jul 16, 2003·Journal of Ethnopharmacology·Catherine Vonthron-SénécheauRobert Anton
Jan 13, 2012·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Mo NafiuM T Yakubu
Oct 3, 2015·Phytochemistry·Aline Lamien-MedaJohannes Novak
Apr 1, 2015·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Zéphirin DakuyoMerlin Willcox
Apr 6, 2007·Molecular and Cellular Biochemistry·Monika BhadauriaSangeeta Shukla
Feb 19, 2021·Frontiers in Pharmacology·André TibiriMaëlle Carraz

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