PMID: 8611335Feb 1, 1996Paper

The hepatorenal syndrome

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
G Van Roey, K Moore

Abstract

Hepatorenal syndrome may occur in any form of severe liver disease. It appears less common in children than adults, but still carries a poor prognosis. There are several factors involved in its aetiology, including a decreased renal perfusion pressure, activation of the renal sympathetic nervous system and increased synthesis of several vasoactive mediators, which may modulate glomerular filtration by acting as both renal vasoconstrictors and dynamic regulators of the glomerular capillary ultrafiltration coefficient, through their action on mesangial cells. This review will discuss the pathophysiology of the hepatorenal syndrome and some of the principles of management of patients with renal failure and severe liver disease. The role of renal support and liver transplantation will also be covered.

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Citations

Jan 31, 2002·World Journal of Gastroenterology : WJG·S R BramhallJ A Buckels
Feb 24, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Martin Kreuzer, Lars Pape
Aug 3, 2016·Journal of Pediatric Gastroenterology and Nutrition·Anshu SrivastavaUjjal Poddar
Oct 2, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Priscila Menezes Ferri LiuAna Cristina Simões E Silva
Aug 1, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Martin KreuzerLars Pape

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