The heritability of leucocyte telomere length dynamics

Journal of Medical Genetics
Jacob B HjelmborgAbraham Aviv

Abstract

Leucocyte telomere length (LTL) is a complex trait associated with ageing and longevity. LTL dynamics are defined by LTL and its age-dependent attrition. Strong, but indirect evidence suggests that LTL at birth and its attrition during childhood largely explains interindividual LTL variation among adults. A number of studies have estimated the heritability of LTL, but none has assessed the heritability of age-dependent LTL attrition. We examined the heritability of LTL dynamics based on a longitudinal evaluation (an average follow-up of 12 years) in 355 monozygotic and 297 dizygotic same-sex twins (aged 19-64 years at baseline). Heritability of LTL at baseline was estimated at 64% (95% CI 39% to 83%) with 22% (95% CI 6% to 49%) of shared environmental effects. Heritability of age-dependent LTL attrition rate was estimated at 28% (95% CI 16% to 44%). Individually unique environmental factors, estimated at 72% (95% CI 56% to 84%) affected LTL attrition rate with no indication of shared environmental effects. This is the first study that estimated heritability of LTL and also its age-dependent attrition. As LTL attrition is much slower in adults than in children and given that having a long or a short LTL is largely determined bef...Continue Reading

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Aug 24, 2002·Pediatric Research·Koji OkudaAbraham Aviv
Feb 21, 2004·Lancet·Tim S NawrotAbraham Aviv
Nov 13, 2004·Experimental Hematology·Bryan E ShepherdJanis L Abkowitz
Mar 18, 2005·Aging Cell·Brad M UnrynKarl T Riabowol
Apr 27, 2005·Circulation·Jeffrey P GardnerAbraham Aviv
Aug 23, 2005·Lancet·A M ValdesT D Spector
Feb 21, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·A AkkadB Williams
Sep 21, 2007·Human Molecular Genetics·Tim De MeyerUNKNOWN Asklepios investigators
Oct 11, 2007·Aging Cell·Stephanie L BakaysaNancy L Pedersen
Jan 30, 2008·Archives of Internal Medicine·Lynn F CherkasAbraham Aviv
Feb 14, 2008·American Journal of Epidemiology·Masayuki KimuraKaare Christensen
Feb 14, 2009·Experimental Hematology·Igor SidorovAbraham Aviv
Feb 9, 2010·Nature Genetics·Veryan CoddNilesh J Samani
Apr 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Daniel LevyAbraham Aviv
Jul 6, 2010·Experimental Hematology·Masayuki KimuraAbraham Aviv
Sep 1, 2011·Mutation Research·Jue LinElizabeth Blackburn
Jan 13, 2012·The American Journal of Clinical Nutrition·Jeremy D KarkAbraham Aviv
Jul 4, 2012·Ageing Research Reviews·Qihua TanKaare Christensen
Feb 23, 2013·European Journal of Epidemiology·Troels SteenstrupAbraham Aviv
Mar 21, 2013·Nature Communications·Lily DanialiAbraham Aviv
Jul 25, 2014·International Journal of Epidemiology·Athanase BenetosAbraham Aviv

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Citations

Feb 22, 2016·Psychoneuroendocrinology·Dóra RévészBrenda W J H Penninx
Jul 21, 2015·Cellular and Molecular Life Sciences : CMLS·Dora MelicherAndras Falus
Aug 26, 2015·Ageing Research Reviews·Mirre J P Simons
Jul 1, 2016·Current Environmental Health Reports·Dries S Martens, Tim S Nawrot
Aug 27, 2016·American Journal of Human Biology : the Official Journal of the Human Biology Council·Sarah ApplebyMartin A Kennedy
Oct 19, 2016·BMC Medicine·Dries S MartensTim S Nawrot
Jul 9, 2016·PLoS Genetics·Rivka C StoneAbraham Aviv
Feb 15, 2017·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Elina SillanpääSarianna Sipilä
Apr 12, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tabea Sarah SendStephanie H Witt
Oct 21, 2017·The Journal of Clinical Endocrinology and Metabolism·Dóra RévészEli Puterman
Apr 24, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Isabel Cristina Ribas WerlangMariana Bohns Michalowski
Sep 12, 2018·Genes, Chromosomes & Cancer·Sivaramakrishna RachakondaRajiv Kumar
Jun 16, 2017·Circulation. Cardiovascular Genetics·Athanase Benetos, Abraham Aviv
Jan 11, 2019·Cells·Camille LaberthonnièreJérôme D Robin
Feb 15, 2019·PLoS Genetics·Christina BauchSimon Verhulst
Jan 18, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Abraham Aviv, Jerry W Shay
Jan 18, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Andrew J Young
Jan 18, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Hannah L Dugdale, David S Richardson
Jan 18, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sonja EntringerPathik D Wadhwa
May 31, 2019·Current Opinion in Psychiatry·Francesco S BersaniOwen M Wolkowitz
May 31, 2019·American Journal of Epidemiology·Laurie GrieshoberHeather M Ochs-Balcom
Sep 14, 2018·Journal of Translational Medicine·Maria TsamouTim S Nawrot
Mar 4, 2020·Cancers·Nalini SrinivasRajiv Kumar
Oct 28, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Athanase BenetosAbraham Aviv
Sep 1, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sanjeev SabharwalAbraham Aviv
May 20, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Abraham Aviv
May 24, 2016·Current Opinion in Hematology·Claudia Bruedigam, Steven W Lane
Apr 11, 2017·Aging·Troels SteenstrupAbraham Aviv
Aug 29, 2019·Aging·Yunsung LeeSteve Horvath
Oct 2, 2019·Translational Psychiatry·Ko Ling ChanPatrick Ip
Nov 20, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Elina SillanpääTaina Rantanen
Nov 21, 2017·Journal of Medical Genetics·Dayana A DelgadoBrandon L Pierce

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