PMID: 9188615Jul 1, 1997Paper

The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency

Journal of Virology
R L Thompson, N M Sawtell

Abstract

Herpes simplex virus type 1 establishes latent infections in sensory neurons. During latency only one locus, the latency-associated transcript (LAT), is abundantly transcribed. Several lines of evidence suggest that this locus is required for the efficient reactivation from latency in experimental models. However, it is not yet clear whether this is a direct effect on the reactivation process per se or, as we have suggested, an indirect effect resulting from a decreased efficiency of establishment of latent infections. In this report wild-type and genetically engineered viral mutants were analyzed in a mouse model using a recently developed approach to precisely quantify latently infected neurons. It was found that strain KOS/M established latent infections, as defined by the presence of the viral genome, in about 30% of the neurons. Thirty-three percent of the mice with this latent viral burden reactivated in vivo following hyperthermic stress. In contrast, mutants in which either the basal LAT promoter or the 5' end of the LAT gene was deleted established latency in only 10% of trigeminal neurons (P < 0.00001), and these mice were impaired for reactivation. Repair of the locus resulted in wild-type levels of establishment and...Continue Reading

References

Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M J FarrellL T Feldman
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Citations

Nov 24, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·C S MillerR J Jacob
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·X J Da CostaD M Knipe
Feb 8, 2003·DNA and Cell Biology·Edward A BurtonJoseph C Glorioso
Jun 28, 2008·Seminars in Ophthalmology·Hassanain S TomaJames M Hill
Oct 24, 2012·Journal of Biomedicine & Biotechnology·Jody M WebreHilary W Thompson
Mar 11, 2016·Journal of Virology·Kevin R MottHomayon Ghiasi
Jan 15, 2003·Clinical Microbiology Reviews·Clinton Jones
Jan 21, 2000·The Journal of General Virology·C M Preston
Dec 24, 2003·International Reviews of Immunology·David C Bloom
Oct 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Qing-Yin WangDavid M Knipe
Feb 12, 2008·Current Protocols in Molecular Biology·N M Sawtell
Jul 11, 2006·Nature·Bill Sugden
Mar 28, 2009·PLoS Pathogens·Richard L ThompsonNancy M Sawtell
Dec 6, 2011·Journal of Neurovirology·Kathrin Held, Tobias Derfuss
Aug 20, 2014·Cephalalgia : an International Journal of Headache·Paul M GadientStephen J Ryan

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