The herpesvirus 8 encoded chemokines vCCL2 (vMIP-II) and vCCL3 (vMIP-III) target the human but not the murine lymphotactin receptor.

Virology Journal
H R Lüttichau

Abstract

Large DNA-viruses such as herpesvirus and poxvirus encode proteins that target and exploit the chemokine system of their host. The Kaposi sarcoma- associated herpes virus (KSHV) encodes three chemokines. Two of these, vCCL2 and vCCL3, target the human lymphotactin receptor as an antagonist and a selective agonist, respectively. Therefore these virally endcoded chemokines have the potential to be used as tools in the study of lymphotactin receptor pathways in murine models. The activities of vCCL2, vCCL3, human lymphotactin (XCL1) and murine lymphotactin (mXCL1) were probed in parallel on the human and murine lymphotactin receptor (XCR1 and mXCR1) using a phosphatidyl-inositol assay. On the human XCR1, vCCL3, mXCL1 and XCL1 acted as agonists. In contrast, only mXCL1 was able to activate the murine lymphotactin receptor. Using the same assay, vCCL2 was able to block the response using any of the three agonists on the humane lymphotactin receptor with IC50s of 2-3 nM. However, vCCL2 was unable to block the response of mXCL1 through the murine lymphotactin receptor. This study shows that vCCL2 and vCCL3 cannot be used to investigate lymphotactin receptor pathways in murine models. These results also add vCCL2 and vCCL3 to a growing...Continue Reading

References

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Citations

Jan 2, 2010·The Journal of Biological Chemistry·Hans R Lüttichau
Jun 8, 2013·Virology Journal·Alma Mariana Fuentes-GonzálezMarcela Lizano
May 4, 2010·Future Virology·John Nicholas
Jul 16, 2008·Chemical Biology & Drug Design·Xiangyang Liang
Mar 11, 2015·Cytokine·Amanda E I ProudfootChristine A Power
Jun 28, 2016·Developmental and Comparative Immunology·Charlotte DeloizyIsabelle Schwartz-Cornil
Oct 5, 2017·International Journal of Molecular Sciences·Michelle C Miller, Kevin H Mayo
Feb 24, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arnar GudjonssonEven Fossum
Dec 25, 2015·Journal of Leukocyte Biology·Martyna Szpakowska, Andy Chevigné

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Datasets Mentioned

BETA
U93872

Methods Mentioned

BETA
NMR
glycosylation
PCR
FCS

Software Mentioned

CLUSTALW
BLASTP

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