The HERV-K accessory protein Np9 controls viability and migration of teratocarcinoma cells

PloS One
Susana M ChanDavid M Markovitz

Abstract

Human endogenous retroviruses are remnants of ancient germline infections that make up approximately 8% of the modern human genome. The HERV-K (HML-2) family is one of the most recent entrants into the human germline, these viruses appear to be transcriptionally active, and HERV-K viral like particles (VLPs) are found in cell lines from a number of human malignancies. HERV-K VLPs were first found to be produced in teratocarcinoma cell lines, and since then teratocarcinoma has been thought of as the classical model for HERV-Ks, with the NCCIT teratocarcinoma cell line particularly known to produce VLPs. Treatment for teratocarcinoma has progressed since its discovery, with improved prognosis for patients. Since the introduction of platinum based therapy, first year survival has greatly improved even with disseminated disease; however, it is estimated that 20% to 30% of patients present with metastatic germ cell tumor relapse following initial treatments. Also, the toxicity associated with the use of chemotherapeutic agents used to treat germ cell tumors is still a major concern. In this study, we show that the depletion of the HERV-K accessory protein Np9 increases the sensitivity of NCCIT teratocarcinoma cells to bleomycin and ...Continue Reading

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Citations

Aug 9, 2020·Frontiers in Microbiology·Bei XueDavid J Kelvin
Apr 23, 2021·PLoS Genetics·Richard M KeeganJosh Dubnau
Jun 1, 2021·Frontiers in Oncology·Eoin DervanSharon A Glynn

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Methods Mentioned

BETA
biopsies
environmental stress
transfection
Flow Cytometry
chemical stress

Software Mentioned

NIS Elements
ImageJ

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