The HET-CAM, a Useful In Vitro Assay for Assessing the Eye Irritation Properties of Cosmetic Formulations and Ingredients

Toxicology in Vitro : an International Journal Published in Association with BIBRA
W SteilingO de Silva

Abstract

One of the most important biological properties of consumer products, and also of many raw materials, is the local compatibility to mucous membranes. Until now standardized in vivo tests are accepted by public health authorities as valid to estimate the irritation potential of chemicals and suitable for the risk assessment. Nevertheless, the controversial discussion on animal tests, and particularly on the Draize rabbit eye test, is increasing in the public and scientific domain. Efforts have been made to validate proper and suitable in vitro tests in international cosmetics industries during the last decade. One of the most important in vitro tests is the HET-CAM, the h en's e gg t est on the c horioa llantoic m embrane of fertilized chicken eggs. In this paper, the efforts to establish the HET-CAM protocol and the defined prediction model (PM) used in the COLIPA (The European Cosmetic, Toiletry and Perfumery Association) study on alternatives to the Draize rabbit eye test are described. Furthermore, the HET-CAM test results of the finalized phase I of the above-mentioned study are discussed in detail. Prior to the COLIPA validation study, the HET-CAM was prevalidated with about 100 test substances covering a broad spectrum of...Continue Reading

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