The heterogeneity of asthma phenotypes in children and young adults.

Journal of Allergy
Bill HesselmarNils Aberg

Abstract

Objective. Genetic heterogeneity and risk factor distribution was analyzed in two previously proposed asthma phenotypes. Method. A sample of 412 subjects was investigated at 7-8, 12-13, and 21-22 years of age with questionnaires, skin prick tests, and genetic analysis of IL-4 receptor (IL4R) single-nucleotide polymorphisms. The sample was subdivided in one group with no asthma, and two groups with asthma separated by age of onset of symptoms, namely, early onset asthma (EOA) and late onset asthma (LOA). Risk factors and IL4R markers were analyzed in respect to asthma phenotypes. Results. EOA and LOA groups were both associated with atopy and a maternal history of asthma. Female gender was more common in LOA, whereas childhood eczema, frequent colds in infancy, and a paternal history of asthma were more common in EOA. The AA genotype of rs2057768 and the GG genotype of rs1805010 were more common in LOA, whereas the GG genotype of rs2107356 was less common in EOA. Conclusion. Our data suggest that early and late onset asthma may be of different endotypes and genotypes.

References

Jan 19, 1995·The New England Journal of Medicine·F D MartinezW J Morgan
Sep 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N AbergB Eriksson
Nov 21, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N KondoY Yokoyama
May 6, 1999·American Journal of Respiratory and Critical Care Medicine·C MarguetJ O Warner
May 7, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B HesselmarB Björkstén
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·W R HendersonC R Maliszewski
Jul 13, 2000·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·B HesselmarN Aberg
Jun 9, 2001·The Journal of Allergy and Clinical Immunology·L C BorishUNKNOWN IL-4R Asthma Study Group
Feb 26, 2004·Paediatric Respiratory Reviews·Andrew Bush
Oct 14, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A-M HytönenL Padyukov
May 25, 2006·Acta Paediatrica·Emma GoksörGöran Wennergren
Jan 25, 2008·The European Respiratory Journal·B D SpycherC E Kuehni
Jul 14, 2010·Pediatrics·Frank D Petruzella, Marc H Gorelick

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Related Concepts

Related Feeds

Acute viral rhinopharyngitis

Acute viral rhinopharyngitis, also known as "common cold", is an acute, self-limiting viral infection of the upper respiratory tract involving the nose, sinuses, pharynx and larynx. Discover the latest research on acute viral rhinopharyngitis here.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.