The heterogeneity of lung macrophages in the susceptibility to disease

European Respiratory Review : an Official Journal of the European Respiratory Society
Luisa Morales-NebredaG R Scott Budinger

Abstract

Alveolar macrophages are specialised resident phagocytes in the alveolus, constituting the first line of immune cellular defence in the lung. As the lung microenvironment is challenged and remodelled by inhaled pathogens and air particles, so is the alveolar macrophage pool altered by signals that maintain and/or replace its composition. The signals that induce the recruitment of circulating monocytes to the injured lung, as well as their distinct gene expression profile and susceptibility to epigenetic reprogramming by the local environment remain unclear. In this review, we summarise the unique characteristics of the alveolar macrophage pool ontogeny, phenotypic heterogeneity and plasticity during homeostasis, tissue injury and normal ageing. We also discuss new evidence arising from recent studies where investigators described how the epigenetic landscape drives the specific gene expression profile of alveolar macrophages. Altogether, new analysis of macrophages by means of "omic" technologies will allow us to identify key pathways by which these cells contribute to the development and resolution of lung disease in both mice and humans.

References

Dec 31, 1997·The Journal of Experimental Medicine·T KuriharaR Bravo
Feb 5, 2002·Annual Review of Physiology·Bruce C Trapnell, Jeffrey A Whitsett
May 9, 2002·British Medical Bulletin·S B Gordon, R C Read
Nov 2, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ulrich A MausJürgen Lohmeyer
Apr 19, 2008·American Journal of Respiratory and Critical Care Medicine·William J JanssenShyra J Gardai
May 29, 2010·Circulation Research·Ajay Chawla
Sep 9, 2010·Cell and Tissue Research·David SchnebergerBaljit Singh
Nov 26, 2010·European Journal of Immunology·Cristel ArchambaudBernard Malissen
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·William J JanssenPeter M Henson
Mar 2, 2012·The Journal of Clinical Investigation·Antonio Sica, Alberto Mantovani
Mar 16, 2013·American Journal of Respiratory Cell and Molecular Biology·Rinat ZaynagetdinovTimothy S Blackwell
Apr 3, 2013·The Journal of Experimental Medicine·Pejman SorooshMichael Croft
May 16, 2013·American Journal of Respiratory Cell and Molecular Biology·Alexander V MisharinHarris Perlman
Oct 16, 2013·The Journal of Experimental Medicine·Atsushi NakamuraKazuhiko Igarashi
Jan 22, 2014·Nature Reviews. Immunology·Tracy Hussell, Thomas J Bell
Jan 28, 2014·Nature·Kristin WestphalenJahar Bhattacharya
Oct 17, 2014·Immunological Reviews·Charlotte L ScottMartin Guilliams
Dec 19, 2014·Nature Immunology·Manfred KopfSamuel P Nobs

❮ Previous
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Citations

Mar 6, 2016·Journal of Nanobiotechnology·Martin WiemannRobert Landsiedel
Mar 17, 2016·Trends in Molecular Medicine·Adam J ByrneClare M Lloyd
Sep 8, 2016·The Journal of Infectious Diseases·David B EttensohnNorbert J Roberts
Jul 31, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·David N O'DwyerBethany B Moore
Jun 20, 2017·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Zane Vitenberga, Mara Pilmane
Jun 15, 2016·Infection and Immunity·Talita D FernandesDario S Zamboni
Sep 18, 2018·Expert Review of Respiratory Medicine·Amlan ChakrabortySimon G Royce
Nov 23, 2018·Experimental Lung Research·Anette Kocbach BøllingLiv Ingunn Bjoner Sikkeland
Dec 28, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Debra L LaskinJeffrey D Laskin
Dec 24, 2018·The European Respiratory Journal·Baishakhi GhoshPeter J Barnes
Jun 16, 2018·The European Respiratory Journal·Martina M De SantisDarcy E Wagner
Jul 1, 2017·Clinical Science·Peter J Barnes
Oct 19, 2019·American Journal of Respiratory and Critical Care Medicine·Elena MitsiDaniela M Ferreira
Apr 8, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brenda F ReaderMegan N Ballinger
Aug 9, 2020·Expert Review of Respiratory Medicine·John StambasRalph A Tripp
Dec 12, 2018·Nature Reviews. Cancer·Nasser K AltorkiVivek Mittal
Jul 18, 2020·Frontiers in Immunology·Rachel G ScheragaMitchell A Olman
Jun 18, 2017·Frontiers in Immunology·Patricia L BrazeeLaura A Dada
Sep 3, 2017·Biotechnology Journal·Katja ZscheppangAndreas C Hocke
Mar 28, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nessrine BellamriLaurent Vernhet
Dec 12, 2019·Scientific Reports·Kazuo TsuchiyaTakafumi Suda
May 30, 2020·American Journal of Respiratory Cell and Molecular Biology·Gregory L SerpaAmanda M Jamieson
Jul 12, 2019·Clinical & Translational Immunology·Helen I Warheit-NiemiBethany B Moore
Aug 9, 2020·Annals of the New York Academy of Sciences·L Cody SmithDebra L Laskin
Dec 7, 2018·Frontiers in Endocrinology·Robert B Hamanaka, Gökhan M Mutlu
Jun 5, 2020·Lipids in Health and Disease·Christina W AgudeloItsaso Garcia-Arcos
May 20, 2017·Frontiers in Immunology·Rachel G ScheragaMitchell A Olman
Sep 12, 2020·American Journal of Respiratory Cell and Molecular Biology·Sreelakshmi VasudevanMehrdad Arjomandi
Oct 31, 2020·Frontiers in Immunology·Jon Hazeldine, Janet M Lord
Dec 17, 2020·Frontiers in Pharmacology·Maria Gracia-HernandezAlejandro Villagra
Feb 18, 2020·Pharmacology & Therapeutics·Kylie B R Belchamber, Louise E Donnelly
Apr 3, 2021·Cellular Immunology·Wei-Jie LiHua-Hao Shen
Apr 12, 2019·International Immunopharmacology·Nessrine BellamriLaurent Vernhet
May 5, 2021·La Revue de médecine interne·P ChauvinA Lescoat
Jun 1, 2021·Frontiers in Pharmacology·Anna M van HeeckerenTracey L Bonfield

❮ Previous
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