The heterogeneity of systemic inflammation in bronchiectasis

Respiratory Medicine
Aarash D SalehJohn R Hurst

Abstract

Systemic inflammation in bronchiectasis is poorly studied in relation to aetiology and severity. We hypothesized that molecular patterns of inflammation may define particular aetiology and severity groups in bronchiectasis. We assayed blood concentrations of 31 proteins from 90 bronchiectasis patients (derivation cohort) and conducted PCA to examine relationships between these markers, disease aetiology and severity. Key results were validated in two separate cohorts of 97 and 79 patients from other centres. There was significant heterogeneity in protein concentrations across the derivation population. Increasing severity of bronchiectasis (BSI) was associated with increasing fibrinogen (rho = 0.34, p = 0.001 -validated in a second cohort), and higher fibrinogen was associated with worse lung function, Pseudomonas colonisation and impaired health-status. There were generally similar patterns of inflammation in patients with idiopathic and post-infectious disease. However, patients with primary immunodeficiency had exaggerated IL-17 responses, validated in a second cohort (n = 79, immunodeficient 12.82 pg/ml versus idiopathic/post-infectious 4.95 pg/ml, p = 0.001), and thus IL-17 discriminated primary immunodeficiency from other...Continue Reading

Citations

Apr 21, 2018·Immunology·Thomas ScamblerDaniel Peckham
Nov 24, 2017·The European Respiratory Journal·Aarash D SalehJohn R Hurst
Jan 27, 2018·The European Respiratory Journal·Sanjay H Chotirmall, James D Chalmers
Jul 28, 2018·The European Respiratory Journal·Eva PolverinoJames D Chalmers
Aug 6, 2019·American Journal of Respiratory and Critical Care Medicine·Miguel Angel Martinez-GarciaAlvar Agusti
Apr 30, 2020·Clinical and Experimental Pharmacology & Physiology·Liyang LiYuanlin Song
Nov 18, 2018·Nature Reviews. Disease Primers·James D ChalmersPamela J McShane
Jul 3, 2019·American Journal of Respiratory and Critical Care Medicine·Simon FinchJames D Chalmers
Apr 17, 2020·Frontiers in Immunology·Luke A WallRicardo U Sorensen
Mar 2, 2018·Annals of the American Thoracic Society·James D Chalmers
Aug 23, 2020·Journal of Clinical Medicine·Rosario MenéndezAntoni Torres
Sep 24, 2020·The Clinical Respiratory Journal·Liyang LiChangzhou Shao
Feb 16, 2021·Expert Review of Respiratory Medicine·David ClofentEva Polverino
Mar 20, 2021·Expert Review of Respiratory Medicine·Celine Vidaillac, Sanjay H Chotirmall
May 19, 2021·Respirology : Official Journal of the Asian Pacific Society of Respirology·Miguel Ángel Martinez-GarciaAlvar Agusti

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