DOI: 10.1101/481283Nov 29, 2018Paper

The Hi-Culfite assay reveals relationships between chromatin contacts and DNA methylation state

BioRxiv : the Preprint Server for Biology
Elena K StamenovaErez Lieberman Aiden


Hi-Culfite, a protocol combining Hi-C and whole-genome bisulfite sequencing (WGBS), determines chromatin contacts and DNA methylation simultaneously. Hi-Culfite also reveals relationships that cannot be seen when the two assays are performed separately. For instance, we show that loci associated with open chromatin exhibit context-sensitive methylation: when their spatial neighbors lie in closed chromatin, they are much more likely to be methylated.

Related Concepts

DNA Methylation
Genetic Loci

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