PMID: 2124615Oct 1, 1990Paper

The hidden mortality in surgically treated necrotizing enterocolitis: fungal sepsis

Journal of Pediatric Surgery
S D SmithM I Rowe

Abstract

From 1979 to 1986, 82 infants underwent surgical treatment for necrotizing enterocolitis (NEC), with 36 deaths. The records of 30 of the 36 infants who died were available for review. Fungal colonization and sepsis, the sites of infection, and timing of diagnosis and therapy were determined. Sixteen of 30 (53%) neonates had no evidence of fungus. Six (20%) were colonized with Candida species. Eight (27%) had fungal sepsis, with two of these eight found only at necropsy. Positive fungal blood cultures were a late finding. In only four of the six patients with positive blood cultures were the results known in time to initiate treatment with amphotericin B. Two of these four babies received less than 2 days of amphotericin B treatment prior to death. Fungal sepsis is a significant lethal factor in the surgical mortality of NEC. Vigorous efforts at earlier diagnosis are mandatory.

References

Apr 1, 1988·Australian Paediatric Journal·H L LokeV Y Yu
Jun 1, 1988·Journal of Pediatric Surgery·H W CheuD A Lloyd
Mar 1, 1987·Archives of Disease in Childhood·H E Cattermole, R P Rivers
Nov 1, 1982·Archives of Disease in Childhood·P N McDougallB D Speidel
Mar 1, 1981·The Journal of Pediatrics·J E BaleyR M Kliegman
Aug 2, 1980·British Medical Journal·M ClarkeC Mitchell
Nov 1, 1980·Archives of Disease in Childhood·S Tuck

❮ Previous
Next ❯

Citations

May 15, 1993·Minerva chirurgica·M MartinelliV Jasonni
Jun 5, 2003·Journal of Pediatric Surgery·Jeffrey S UppermanHenri R Ford
Sep 1, 1993·Archives of Disease in Childhood·M D Stringer, L Spitz
May 12, 2000·Seminars in Pediatric Surgery·J C Chandler, A Hebra
Aug 1, 1994·Journal of Pediatric Surgery·M I RoweP J Healey
Feb 14, 2015·Clinics in Perinatology·Sarah A CogginsJörn-Hendrik Weitkamp
Apr 30, 2004·Journal of Perinatology : Official Journal of the California Perinatal Association·K L Siu, W H Lee
Jan 13, 2000·Journal of Chemotherapy·B J KhooryV Fanos
May 1, 1993·World Journal of Surgery·R A Amoury
May 11, 2010·Fetal and Pediatric Pathology·Carlos E Parra-HerranMaria M Rodriguez
Jul 1, 1995·Antimicrobial Agents and Chemotherapy·J N van den AnkerP J Sauer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Indian Journal of Pediatrics
A RoyP Chakraborty
Journal of Perinatology : Official Journal of the California Perinatal Association
W Pumberger, W Novak
© 2021 Meta ULC. All rights reserved