The high affinity IgE receptor (FcεRI) expression and function in airway smooth muscle

Pulmonary Pharmacology & Therapeutics
Naresh Singh Redhu, Abdelilah S Gounni

Abstract

The airway smooth muscle (ASM) is no longer considered as merely a contractile apparatus and passive recipient of growth factors, neurotransmitters and inflammatory mediators signal but a critical player in the perpetuation and modulation of airway inflammation and remodeling. In recent years, a molecular link between ASM and IgE has been established through Fc epsilon receptors (FcεRs) in modulating the phenotype and function of these cells. Particularly, the expression of high affinity IgE receptor (FcεRI) has been noted in primary human ASM cells in vitro and in vivo within bronchial biopsies of allergic asthmatic subjects. The activation of FcεRI on ASM cells suggests a critical yet almost completely ignored network which may modulate ASM cell function in allergic asthma. This review is intended to provide a historical perspective of IgE effects on ASM and highlights the recent updates in the expression and function of FcεRI, and to present future perspectives of activation of this pathway in ASM cells.

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Citations

Apr 12, 2014·PloS One·Jyoti BalharaAbdelilah S Gounni
Feb 7, 2014·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Naresh Singh RedhuAbdelilah S Gounni
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Aug 13, 2021·American Journal of Rhinology & Allergy·Cecelia DamaskChristine Franzese
Sep 19, 2021·Clinical Reviews in Allergy & Immunology·Philippe GevaertTara F Carr

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