PMID: 7536472Apr 12, 1995Paper

The high-conductance channel of porin-less yeast mitochondria

Biochimica Et Biophysica Acta
I SzabóM Zoratti

Abstract

Patch-clamp and planar bilayer experiments on porin-less yeast mitochondria have allowed the characterization of a cationic channel activated at matrix-side positive (unphysiological) potentials. In voltage-pulse experiments, inactivation was a faster process than activation and the time constant for inactivation was more steeply dependent on voltage than the one for activation. The channel exhibited various conductance states whose occupancy depended on the applied transmembrane potential. In bilayer experiments, the presence of the pCOx-IV leader peptide induced fast gating in a voltage-dependent manner. A comparison with previously described activities suggests that the pore may coincide with the peptide-sensitive channel (PSC) (Thieffry et al. (1988) EMBO J. 7, 1449-1454) as well as with two other activities (Dihanich et al. (1989) Eur. J. Biochem. 181, 703-708; Tedeschi et al. (1987) J. Membr. Biol. 97, 21-29) assigned to the mitochondrial outer membrane. The possible relationship of this channel to the mitochondrial megachannel is discussed.

References

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Citations

Mar 10, 2005·Neurobiology of Disease·Paula I MoreiraCatarina R Oliveira
Dec 29, 2004·Biochimica Et Biophysica Acta·Mario ZorattiUmberto De Marchi
Apr 1, 1996·Journal of Bioenergetics and Biomembranes·K W KinnallyC A Mannella
Apr 1, 1996·Journal of Bioenergetics and Biomembranes·C Ballarin, M C Sorgato
Apr 1, 1996·Journal of Bioenergetics and Biomembranes·G BathoriM Zoratti
Apr 3, 2014·Physiological Reviews·Ildiko Szabo, Mario Zoratti
Jul 7, 1995·The Journal of Biological Chemistry·T A Lohret, K W Kinnally
May 3, 2014·The Journal of Biological Chemistry·Michela CarraroPaolo Bernardi
Aug 22, 1997·The Journal of Biological Chemistry·D W JungD R Pfeiffer

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