The high-frequency major histocompatibility complex class I allele Mamu-B*17 is associated with control of simian immunodeficiency virus SIVmac239 replication.

Journal of Virology
Levi J YantDavid I Watkins

Abstract

Particular HLA alleles are associated with reduced human immunodeficiency virus replication. It has been difficult, however, to characterize the immune correlates of viral control. An analysis of the influence of major histocompatibility complex class I alleles on viral control in 181 simian immunodeficiency virus SIVmac239-infected rhesus macaques revealed that Mamu-B(*)17 was associated with a 26-fold reduction in plasma virus concentrations (P<0.001). Mamu-B(*)17 was also enriched in a group of animals that controlled viral replication by 1,000-fold [corrected] Even after accounting for this group, Mamu-B(*)17 was associated with an eightfold reduction in plasma virus concentrations (P<0.001). Mamu-B(*)17-positive macaques could, therefore, facilitate our understanding of the correlates of viral control.

References

Mar 1, 1996·QJM : Monthly Journal of the Association of Physicians·A J McNeilJ R Robertson
Jun 15, 1997·Annals of Internal Medicine·J W MellorsC R Rinaldo
Mar 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·S A MiguelesM Connors
Jun 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bianca R MothéAlessandro Sette
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thorsten MühlUlrike Sauermann
Jan 15, 2003·Annual Review of Medicine·Mary Carrington, Stephen J O'Brien
Dec 14, 2004·Nature·Photini KiepielaPhilip J R Goulder

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Citations

Mar 27, 2007·Immunogenetics·Shelby L O'ConnorDavid H O'Connor
Dec 22, 2007·Immunogenetics·Julie A KarlDavid H O'Connor
Dec 25, 2008·Immunogenetics·Kevin J CampbellDavid H O'Connor
Jul 7, 2011·Immunogenetics·Jason S ReedNancy A Wilson
Nov 9, 2007·Immunologic Research·Benjamin Bimber, David H O'Connor
Nov 18, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Marcio O LasaroHildegund C Ertl
Jul 12, 2008·Nature Reviews. Immunology·Philip J R Goulder, David I Watkins
Sep 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Margherita RosatiGeorge N Pavlakis
May 12, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yongjun SuiJay A Berzofsky
Oct 24, 2007·The Journal of Experimental Medicine·Nicholas J ManessDavid I Watkins
Oct 8, 2008·The Journal of Experimental Medicine·Matthew R ReynoldsDavid I Watkins
Mar 7, 2013·AIDS Research and Human Retroviruses·Katherine ButlerEllen N Kersh
Nov 1, 2013·ILAR Journal·Roger W WisemanDavid H O'Connor
Jun 29, 2012·The Journal of Infectious Diseases·Ellen N KershJ Gerardo Garcia-Lerma
Jul 24, 2013·The Journal of Infectious Diseases·Holly JanesNicole Frahm
Mar 24, 2012·AIDS·Adrian B McDermott, Richard A Koup
Apr 5, 2012·Cold Spring Harbor Perspectives in Medicine·Amalio Telenti, Welkin E Johnson
Jun 1, 2012·Science Translational Medicine·Dennis J Hartigan-O'ConnorJoseph M McCune
May 20, 2011·Journal of Virology·Philip A MuddDavid I Watkins
Jun 1, 2007·Journal of Virology·John T LoffredoDavid I Watkins

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