The high-fructose intake of dams during pregnancy and lactation exerts sex-specific effects on adult rat offspring metabolism.

Journal of Developmental Origins of Health and Disease
Francisca A Tobar-BernalLucía Quevedo-Corona

Abstract

Experimental studies have demonstrated the effects of maternal fructose consumption during pregnancy and lactation on metabolic alterations in their offspring, especially male offspring. However, few studies have focused on female offspring after providing fructose in food to dam rats. Here, we studied whether offspring of both sexes were differentially affected by a maternal high-fructose diet (HFD). For this purpose, Sprague-Dawley rats were fed during pregnancy and lactation with a standard diet (SD) or a HFD (50% w/w). After weaning, offspring were fed an SD; 3 days later, dams were sacrificed, and their offspring were sacrificed on postnatal day 90. Body weight (BW), food and water intake (only for dams), and various biomarkers of metabolic syndrome were measured. When compared to the SD-fed dams, HFD-fed dams had a reduction in BW and food and water intake. Conversely, adiposity, liver weight, liver lipids, and plasma levels of glucose, insulin, cholesterol, triglycerides, and uric acid were increased in HFD-fed dams. Moreover, the BW, food consumption, weight of retroperitoneal fat pads, and liver lipids increased in female and male offspring of HFD-fed dams. Interestingly, the pups of HFD-fed mothers showed increased le...Continue Reading

References

Sep 1, 1990·Developmental Psychobiology·E ThielsC P Cramer
Jun 26, 2001·Diabetes/metabolism Research and Reviews·S Del Prato, A Tiengo
May 3, 2003·Neuropharmacology·J Harvey, M L J Ashford
Aug 4, 2005·Obesity Research·Hella JürgensMatthias H Tschöp
Jul 17, 2008·Regulatory Peptides·Andreas LindqvistCharlotte Erlanson-Albertsson
Jan 20, 2009·Endocrine Reviews·Richard J JohnsonTakahiko Nakagawa
Dec 24, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S E Perez-PozoJ López Lillo
Jan 21, 2010·Physiological Reviews·Luc Tappy, Kim-Anne Lê
Jun 4, 2011·ISRN Obstetrics and Gynecology·Vera L MorettoMaria Helena G Gomes-da-Silva
Jun 21, 2011·Current Problems in Pediatric and Adolescent Health Care·Kara Calkins, Sherin U Devaskar
Oct 20, 2011·Nutrition Research Reviews·Roberto Berni CananiCarlo Agostoni
Nov 24, 2011·Diabetes & Metabolism Journal·Ji-Won Kim, Kun-Ho Yoon
Nov 23, 2012·Globalization and Health·Carla Silva-Matos, David Beran
Jul 23, 2013·Biochimica Et Biophysica Acta·Lyda WilliamsMaureen J Charron
Sep 17, 2013·Clinical and Experimental Pharmacology & Physiology·Timothy R H RegnaultDeborah M Sloboda
Jul 26, 2014·Annals of Nutrition & Metabolism·M H Vickers
Jan 21, 2015·Trends in Molecular Medicine·Moshe Szyf
Feb 11, 2015·Trends in Molecular Medicine·Shalini OjhaMichael E Symonds
Mar 13, 2015·Journal of Nutrition and Metabolism·Lourdes RodríguezCarlos Bocos
Mar 15, 2015·The Journal of Nutritional Biochemistry·You-Lin TainJulie Y H Chan
Mar 25, 2015·Journal of Clinical Research in Pediatric Endocrinology·Erkan SarıAhmet Güven
Oct 3, 2015·Journal of the American College of Cardiology·Vasanti S Malik, Frank B Hu
Jun 11, 2016·Journal of the American Society of Nephrology : JASN·Richard J JohnsonLaura G Sánchez-Lozada
Sep 9, 2018·Progress in Neurobiology·Julie A ChowenJesús Argente
Apr 24, 2019·The Journal of Endocrinology·Patrycja A Jazwiec, Deborah M Sloboda

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Citations

May 6, 2021·International Journal of Molecular Sciences·Purificación RosJulie A Chowen

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