PMID: 8588492Jan 1, 1994Paper

The higher rate of multiple births after periconceptional multivitamin supplementation: an analysis of causes

Acta geneticae medicae et gemellologiae
Andrew E CzeizelI Dudás

Abstract

A randomized controlled trial of periconceptional multivitamin supplementation (including 0.8 mg folic acid--see the Materials and Methods section for the precise composition of the multivitamin and trace-element supplementation) was carried out for at least 28 days before conception. The trial was continued until at least until the second missed menstrual period to test the effectiveness of this new primary preventive method in the reduction of neural tube defects. However, other pregnancy outcomes were also evaluated. Of a total of 5,502 pregnant women, 4,846 births were analysed in the final data base. The rate of multiple births was significantly higher in the multivitamin group (3.8%) than in the placebo-like trace-element control group (2.7%), and in both groups exceeded the multiple birth rate of 2.2% in the Hungarian population at large. 7.3% of women in the multivitamin and 7.9% of women in the trace-element groups had received ovarian stimulation treatment (mainly clomiphene) for hormonal dysfunctions, eg. anovulation. Nonetheless, our study showed that periconceptional multivitamin supplementation, with or without ovarian stimulation, increases the rate of multiple births.

References

Dec 24, 1992·The New England Journal of Medicine·A E Czeizel, I Dudás
Jul 15, 1989·Lancet·A Czeizel
Feb 1, 1989·Journal of Animal Science·M D Lindemann, E T Kornegay
Jan 1, 1988·Journal of Medical Genetics·A Czeizel
Oct 1, 1984·Journal of Animal Science·J J MatteG J Brisson
Jan 1, 1983·Acta Obstetricia Et Gynecologica Scandinavica·A L Hartikainen-SorriM Koivisto
Mar 1, 1981·British Journal of Obstetrics and Gynaecology·M C O'ConnorI J Dalrymple
Apr 17, 1993·Lancet·W WillemsenR Rolland
Jun 9, 1994·The New England Journal of Medicine·A E CzeizelI Dudás

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Citations

May 9, 2000·The American Journal of Clinical Nutrition·T O Scholl, W G Johnson
Feb 20, 2007·Human Reproduction Update·Thierry ForgesJ L Guéant
Dec 15, 2015·The Cochrane Database of Systematic Reviews·Luz Maria De-RegilPura Rayco-Solon
May 7, 2016·The Cochrane Database of Systematic Reviews·Olukunmi O BalogunRintaro Mori
Aug 5, 2004·Obstetrics and Gynecology·John C SmulianAnthony M Vintzileos
Apr 15, 2011·The Cochrane Database of Systematic Reviews·Judith LumleyCarol Bower
Dec 17, 2008·The American Journal of Clinical Nutrition·Mary Frances Picciano, Michelle K McGuire
Apr 2, 2005·Obstetrics and Gynecology·Caroline SignoreAnn C Trumble
Dec 2, 2015·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Julia Métneki
Sep 21, 2001·BJOG : an International Journal of Obstetrics and Gynaecology·J LumleyC Bower
Jul 2, 2008·Public Health Nutrition·Tanya Gk BentleyKaren M Kuntz

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