PMID: 9192700Jun 24, 1997Paper

The hippocampus and memory for orderly stimulus relations

Proceedings of the National Academy of Sciences of the United States of America
J A Dusek, H Eichenbaum

Abstract

Human declarative memory involves a systematic organization of information that supports generalizations and inferences from acquired knowledge. This kind of memory depends on the hippocampal region in humans, but the extent to which animals also have declarative memory, and whether inferential expression of memory depends on the hippocampus in animals, remains a major challenge in cognitive neuroscience. To examine these issues, we used a test of transitive inference pioneered by Piaget to assess capacities for systematic organization of knowledge and logical inference in children. In our adaptation of the test, rats were trained on a set of four overlapping odor discrimination problems that could be encoded either separately or as a single representation of orderly relations among the odor stimuli. Normal rats learned the problems and demonstrated the relational memory organization through appropriate transitive inferences about items not presented together during training. By contrast, after disconnection of the hippocampus from either its cortical or subcortical pathway, rats succeeded in acquiring the separate discrimination problems but did not demonstrate transitive inference, indicating that they had failed to develop o...Continue Reading

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Citations

Sep 14, 2000·Hippocampus·R C O'Reilly, J W Rudy
Apr 18, 2003·Hippocampus·Craig E L Stark, Larry R Squire
Apr 26, 2001·Journal of Physiology and Biochemistry·J M Ramos, J M Vaquero
May 20, 2009·Psychological Research·Sandra N MosesJennifer D Ryan
Jun 25, 2013·Cell and Tissue Research·Fabio Morellini
Jul 1, 2006·Animal Cognition·Joanna J Bryson, Jonathan C S Leong
Feb 22, 2012·Animal Cognition·Clint Perry, Gidon Felsen
Jul 16, 2008·Cognitive Processing·Ronaldo Vigo, Colin Allen
Jul 1, 2005·Current Neurology and Neuroscience Reports·Alison R PrestonAnthony D Wagner
Dec 27, 2012·Journal of Experimental Child Psychology·Jenny L Richmond, Rose Pan
Aug 26, 1999·Life Sciences·R E Hampson, S A Deadwyler
Sep 3, 2002·Neuroscience and Biobehavioral Reviews·Ora Kofman
Aug 28, 1998·Trends in Neurosciences·G V WallensteinM E Hasselmo
Nov 24, 2001·Behavioural Brain Research·H Eichenbaum
Oct 8, 1999·Behavioural Brain Research·H Eichenbaum
Dec 14, 1999·Behavioural Brain Research·V I Arkhipov
Dec 28, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Carol HudonSonia Goulet
Feb 13, 2001·Schizophrenia Research·J ZahajszkyM E Shenton
Apr 22, 2004·Schizophrenia Research·Debra TitoneDeborah L Levy
Feb 7, 2001·Current Opinion in Neurobiology·R P KesnerG V Wallenstein
Apr 27, 2001·Trends in Cognitive Sciences·B Slotnick
May 11, 1999·Trends in Cognitive Sciences·D GriffithsN Clayton
Feb 26, 2004·Behavioral Neuroscience·Mark J BuckleyDavid Gaffan
Sep 29, 2005·Behavioral Neuroscience·Faith M HanlonJose M Cañive
Feb 27, 2008·Behavioral Neuroscience·Andrea M BrushfieldPaul E Gilbert
Sep 2, 2008·Nature Neuroscience·Itaru ImayoshiRyoichiro Kageyama
Jan 29, 2013·Nature Neuroscience·Robert Stickgold, Matthew P Walker
Jan 29, 2013·Nature Neuroscience·György Buzsáki, Edvard I Moser

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