The Hippocampus and Social Impairment in Psychiatric Disorders

Cold Spring Harbor Symposia on Quantitative Biology
Matthew Schafer, Daniela Schiller

Abstract

Social deficits, such as poor social skills (i.e., the inability to engage in appropriate and effective social interactions) and social withdrawal, are prevalent across psychiatric disorders and often co-occur with hippocampal structural and functional abnormalities. The centrality of both social and hippocampal dysfunction in psychiatric research prompts the question: Are they linked? The social cognitive map framework provides a clue: The hippocampus tracks social information in the physical environment, maps others along social dimensions, and supports social memory and decision-making. Hippocampal dysfunction might disrupt social map representation and contribute to commonly seen social behavioral symptoms. This review summarizes evidence for the role of the hippocampus in social cognitive mapping, followed by evidence that hippocampal dysfunction and social dysfunction co-occur in psychiatric disorders. We argue that the co-occurrence of hippocampal and social impairment may be related via hippocampal social cognitive mapping.

References

Apr 1, 1992·Archives of General Psychiatry·F R SchneierM M Weissman
Jul 1, 1985·Archives of General Psychiatry·M R LiebowitzD F Klein
Oct 1, 1985·Cognition·S Baron-CohenU Frith
Jan 1, 1971·Brain : a Journal of Neurology·H I Sanders, E K Warrington
Jan 1, 1996·Acta Neuropathologica·G V RaymondT L Kemper
Aug 1, 1996·Archives of Psychiatric Nursing·B M HagertyM R Early
Jan 1, 1996·Memory & Cognition·J M WilliamsA K MacLeod
Oct 6, 1997·The British Journal of Clinical Psychology·L GoddardA Burton
Apr 26, 2000·Clinical Psychology Review·C Segrin
Apr 4, 2001·The European Journal of Neuroscience·E IsovichE Fuchs
Jan 25, 2002·Journal of Child Psychology and Psychiatry, and Allied Disciplines·N J Minshew, G Goldstein
Jan 30, 2002·Journal of Autism and Developmental Disorders·G J BlattM L Bauman
Nov 1, 2002·Schizophrenia Research·Jane E AndersonMartha E Shenton
Nov 7, 2002·Archives of General Psychiatry·Murray B SteinGregory G Brown
Dec 4, 2002·Biological Psychiatry·Maria TillforsMats Fredrikson
Jan 7, 2003·Child and Adolescent Psychiatric Clinics of North America·Lori KrasnySally Ozonoff
Jan 7, 2004·Molecular Psychiatry·Michael B KnableUNKNOWN Stanley Neuropathology Consortium
Jun 26, 2004·Annual Review of Neuroscience·Thomas R Insel, Russell D Fernald
Jul 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cynthia Mills SchumannDavid G Amaral
Nov 4, 2004·Biological Psychiatry·Craig A StockmeierGrazyna Rajkowska
Dec 29, 2004·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Diane L WilliamsNancy J Minshew
Apr 6, 2005·Archives of General Psychiatry·Andreas S Meyer-LindenbergKaren Faith Berman
Jun 21, 2005·Nature·Torkel HaftingEdvard I Moser
Jan 13, 2006·Biological Psychiatry·Noriomi KurokiMartha E Shenton
Jun 9, 2006·Neuropsychologia·Alexander TodorovJames V Haxby
Jul 25, 2006·Psychiatry Research·Amy E Pinkham, David L Penn
Nov 30, 2006·Neuropsychologia·Chris M BirdLisa Cipolotti
Mar 14, 2007·Cognitive Neuropsychiatry·Peter J UhlhaasSteven M Silverstein
Aug 2, 2007·The British Journal of Psychiatry : the Journal of Mental Science·Benoit BediouImane Tazi

❮ Previous
Next ❯

Citations

Jul 31, 2019·Cold Spring Harbor Symposia on Quantitative Biology·Adam Kepecs
Jan 31, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Giorgi LobzhanidzeMzia Zhvania

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Frontiers in Neuroscience
Matthew A J AppsJoshua H Balsters
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Daniela SchillerCharan Ranganath
© 2022 Meta ULC. All rights reserved