PMID: 9438792Jan 23, 1998Paper

The hippocampus, objects, and their contexts

Behavioral Neuroscience
H J Cassaday, J N Rawlins

Abstract

Rats with hippocampal aspiration lesions and controls were trained on delayed nonmatching to sample with small complex goal boxes, presented trial uniquely. A series of experiments then used pairs of large or small boxes, presented repeatedly. The lesions impaired choice accuracy when the rats were tested with large empty boxes but not when small boxes containing 3-dimensional objects were used. There was a comparable impairment when the rats were tested with pairs of large complex boxes, which contained arrays of objects, identical to those used in the smaller boxes but necessarily spaced further apart. Subsequent experiments revealed that the lesion deficit with large boxes was reduced by insertion of a continuous line of distinctive objects and eliminated by trial-unique presentation of large boxes. The results are discussed in terms of (non) spatial accounts of hippocampal function and the compensatory effects of novel object cues. We conclude that, for hippocampal rats, spatial cues, although useless, can nonetheless be profoundly disruptive.

Citations

May 19, 2000·Neuroscience and Biobehavioral Reviews·M Colombo, N Broadbent
Nov 24, 2001·Behavioural Brain Research·A D Redish
Sep 13, 2001·The European Journal of Neuroscience·K GuentherJ N Rawlins
Oct 1, 2005·The Quarterly Journal of Experimental Psychology. B, Comparative and Physiological Psychology·John P Aggleton, Malcolm W Brown
Oct 1, 2005·The Quarterly Journal of Experimental Psychology. B, Comparative and Physiological Psychology·Elisabeth A MurrayDavid Gaffan
Feb 7, 2001·Annual Review of Psychology·E T Rolls
Mar 3, 2011·Cellular and Molecular Life Sciences : CMLS·Zafar U KhanMark G Baxter
Jan 28, 2012·Neuropharmacology·Ashley M MelichercikBoyer D Winters
Mar 24, 2010·Behavioural Brain Research·Edmund T Rolls
May 24, 2008·Neuroscience and Biobehavioral Reviews·Boyer D WintersTimothy J Bussey
Dec 25, 2004·Behavioural Brain Research·Robert M J DeaconP Rawlins
Jul 1, 2004·Neuroscience and Biobehavioral Reviews·D M BannermanJ Feldon
Oct 10, 2006·Epilepsy & Behavior : E&B·Tatiana N ShatskikhGregory L Holmes
Jun 20, 2006·Progress in Neurobiology·Edmund T Rolls, Raymond P Kesner
Jan 21, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Edmund T Rolls
Dec 3, 2014·Behavioural Brain Research·Jasper Robinson, Charlotte Bonardi
Feb 6, 2010·Neuropsychologia·Boyer D WintersTimothy J Bussey
Dec 3, 2014·Neuroscience and Biobehavioral Reviews·Raymond P Kesner, Edmund T Rolls

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