The hippocampus participates in a pharmacological rat model of absence seizures

Epilepsy Research
Justin ArcaroL Stan Leung

Abstract

Using the gamma-butyrolactone (GBL) model of absence seizures in Long-Evans rats, this study investigated if 2.5-6 Hz paroxysmal discharges (PDs) induced by GBL were synchronized among the thalamocortical system and the hippocampus, and whether inactivation of the hippocampus affected PDs. Local field potentials were recorded by chronically implanted depth electrodes in the neocortex (frontal, parietal, visual), ventrolateral thalamus and dorsal hippocampal CA1 area. In separate experiments, multiple unit recordings were made at the hippocampal CA1 pyramidal cell layer, or the mid-septotemporal hippocampus was inactivated by local infusion of GABAA receptor agonist muscimol. As PDs developed following GBL injection, coherence of local field potentials at 2.5-6 Hz increased between the hippocampus and thalamus, and between the hippocampus and the neocortex. Hippocampal theta rhythm was disrupted when GBL induced immobility in the rats. The probability of hippocampal multiple unit firing significantly increased at 40-80 ms prior to the negative peak of thalamic PDs. Coherence between hippocampal multiple unit activity and thalamic field potentials at 2.5-6 Hz was significantly increased after GBL injection. Muscimol infusion to i...Continue Reading

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Citations

Aug 24, 2016·NeuroImage. Clinical·Manuela TondelliStefano Meletti
Nov 2, 2016·Socioaffective Neuroscience & Psychology·Adam Safron
Apr 19, 2020·Clinical and Experimental Pharmacology & Physiology·Sathiya SekarChangiz Taghibiglou
Dec 12, 2020·Seizure : the Journal of the British Epilepsy Association·Tianyu ZhangTianhua Yang
Jul 14, 2021·Neuroscience Letters·Enes AkyuzLeonid S Godlevsky

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