The histamine H3R antagonist DL77 attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism

Scientific Reports
Nermin EissaBassem Sadek

Abstract

Autistic spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairment in social communication and restricted/repetitive behavior patterns or interests. Antagonists targeting histamine H3 receptor (H3R) are considered potential therapeutic agents for the therapeutic management of different brain disorders, e.g., cognitive impairments. Therefore, the effects of subchronic treatment with the potent and selective H3R antagonist DL77 (5, 10, or 15 mg/kg, i.p.) on sociability, social novelty, anxiety, and aggressive/repetitive behavior in male Tuck-Ordinary (TO) mice with ASD-like behaviors induced by prenatal exposure to valproic acid (VPA, 500 mg/kg, i.p.) were evaluated using the three-chamber test (TCT), marble burying test (MBT), nestlet shredding test (NST), and elevated plus maze (EPM) test. The results showed that VPA-exposed mice exhibited significantly lower sociability and social novelty preference compared to VPA-exposed mice that were pretreated with DL77 (10 or 15 mg/kg, i.p.). VPA-exposed mice presented a significantly higher percentage of buried marbles in MBT and shredded nestlet significantly more in NST compared to the control groups. However, VPA-exposed animals pretreated with DL77 (10 or ...Continue Reading

References

Sep 1, 1991·Trends in Neurosciences·H WadaT Watanabe
Feb 13, 2001·Progress in Neurobiology·R E BrownH L Haas
Feb 6, 2002·Brain Research Bulletin·Christian Andres
Jul 27, 2002·Molecular Psychiatry·D C Chugani
Aug 15, 2002·Pharmacology, Biochemistry, and Behavior·Gerard B FoxMichael W Decker
Feb 28, 2003·The Journal of Pharmacology and Experimental Therapeutics·Gerard B FoxArthur A Hancock
Nov 11, 2003·Genes, Brain, and Behavior·J L R Rubenstein, M M Merzenich
Dec 18, 2003·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Manuel F CasanovaJuan Gomez
Apr 1, 2004·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·G B FoxA A Hancock
Sep 4, 2004·Genes, Brain, and Behavior·J J NadlerJ N Crawley
Jan 25, 2005·Mental Retardation and Developmental Disabilities Research Reviews·Jacqueline N Crawley
Feb 10, 2006·Bioorganic & Medicinal Chemistry·Dorota ŁazewskaKatarzyna Kieć-Kononowicz
Aug 10, 2006·Journal of Autism and Developmental Disorders·Helen H L Wong, Ronald G Smith
Sep 16, 2006·Journal of Autism and Developmental Disorders·Ellen HansonJudith Petry
Mar 4, 2008·Neuroscience Letters·Elena V OrekhovaMikael Elam
May 21, 2008·Bioorganic & Medicinal Chemistry·Jadwiga HandzlikKatarzyna Kieć-Kononowicz
Jul 16, 2008·Physiological Reviews·Helmut L HaasOliver Selbach
Dec 2, 2008·Biological & Pharmaceutical Bulletin·Kerstin SanderHolger Stark
May 25, 2010·Neuropharmacology·Farhad Jadidi-Niaragh, Abbas Mirshafiey
Jun 19, 2010·Nature Reviews. Neuroscience·Jill L SilvermanJacqueline N Crawley
Sep 25, 2010·The Journal of Pharmacology and Experimental Therapeutics·Jorge D BrioniMarlon D Cowart
Feb 18, 2011·Trends in Pharmacological Sciences·Maria Beatrice Passani, Patrizio Blandina
Nov 19, 2011·The International Journal of Neuropsychopharmacology·Shunsuke KataokaToshio Matsuda
Mar 2, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Amine Bahi, Jean-Luc Dreyer
May 10, 2012·Journal of Neuroinflammation·Raquel FerreiraLiliana Bernardino
May 15, 2012·Pharmacological Reports : PR·Danish MahmoodMohd Akhtar
Oct 8, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Golan Karvat, Tali Kimchi
Oct 15, 2013·Autism Research : Official Journal of the International Society for Autism Research·Luciana Lucchina, Amaicha Mara Depino
Dec 4, 2013·International Review of Neurobiology·Peristera PaschouPieter J Hoekstra
Jan 17, 2014·Journal of Visualized Experiments : JoVE·Mariana Angoa-PérezDonald M Kuhn
May 13, 2014·Frontiers in Cellular Neuroscience·Sandra M RochaLiliana Bernardino
Sep 30, 2014·Neuroscience Letters·Victorio Bambini-JuniorCarmem Gottfried
Jun 19, 2015·Pharmacological Reviews·Pertti PanulaHelmut L Haas
Aug 19, 2015·Neuropharmacology·Maximiliano Rapanelli, Christopher Pittenger

❮ Previous
Next ❯

Citations

Aug 29, 2020·Journal of Psychopharmacology·Ana Cvv GiacominiMurilo S de Abreu
Dec 14, 2018·Frontiers in Cellular Neuroscience·Hsiao-Ying Kuo, Fu-Chin Liu
Nov 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alaa AlachkarBassem Sadek
Oct 28, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Alinne Lorrany Gomes Dos SantosDaniel Guerreiro Diniz
Jan 26, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Geir BjørklundSalvatore Chirumbolo
Mar 26, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Abdoh TalebFeng Han
Sep 4, 2020·European Journal of Medicinal Chemistry·Dorota ŁażewskaKatarzyna Kieć-Kononowicz
Mar 28, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Karthikkumar VenkatachalamBassem Sadek
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kamil J KuderKatarzyna Kieć-Kononowicz
Aug 3, 2021·Frontiers in Neuroscience·Elliott Carthy, Tommas Ellender
Aug 19, 2020·Developmental Neuroscience·Devahuti ChalihaJohn Mamo

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
Enzyme-linked Immunosorbent Assay
Protein Assay
MDA

Software Mentioned

EthoVision
SPSS

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.