Abstract
In the present study, we investigated the influence of blockade of the serotoninergic and histaminergic neurotransmitter system on the anorectic effect of IP-injected amylin in rats. In 12- or 24-h food-deprived rats, blockade of central and peripheral serotonin (5-HT) receptors with the 5-HT1 and 5-HT2 receptor antagonist metergoline (0.5 or 0.05 mg/kg, IP, respectively) did not seem to influence the anorectic effect of IP injected amylin (1 microgram/kg). Similarly, inhibition of 5-HT synthesis and release with the 5-HT1A receptor agonist (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide (200 micrograms/kg, IP) did not diminish amylin's (5 micrograms/kg, IP) anorectic effect in 24-h food-deprived rats whereas that of CCK (3 micrograms/kg, IP) was blocked under comparable conditions. Pretreatment of rats with the histamine H3 receptor agonists R-alpha-methylhistamine (MH: 3 mg/kg, IP) and Imerit (3 mg/kg, IP), which block transmission in the histaminergic system by inhibiting release of endogenous histamine, attenuated amylin's (1 microgram/kg) anorectic effect in 24-h food-deprived rats. These results suggest that the histaminergic system in involved in transduction of IP amylin's inhibitory effect on feeding in rats....Continue Reading
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