PMID: 8971926Jan 1, 1996Paper

The histaminergic, but not the serotoninergic, system mediates amylin's anorectic effect

Peptides
Thomas Alexander LutzE Scharrer

Abstract

In the present study, we investigated the influence of blockade of the serotoninergic and histaminergic neurotransmitter system on the anorectic effect of IP-injected amylin in rats. In 12- or 24-h food-deprived rats, blockade of central and peripheral serotonin (5-HT) receptors with the 5-HT1 and 5-HT2 receptor antagonist metergoline (0.5 or 0.05 mg/kg, IP, respectively) did not seem to influence the anorectic effect of IP injected amylin (1 microgram/kg). Similarly, inhibition of 5-HT synthesis and release with the 5-HT1A receptor agonist (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide (200 micrograms/kg, IP) did not diminish amylin's (5 micrograms/kg, IP) anorectic effect in 24-h food-deprived rats whereas that of CCK (3 micrograms/kg, IP) was blocked under comparable conditions. Pretreatment of rats with the histamine H3 receptor agonists R-alpha-methylhistamine (MH: 3 mg/kg, IP) and Imerit (3 mg/kg, IP), which block transmission in the histaminergic system by inhibiting release of endogenous histamine, attenuated amylin's (1 microgram/kg) anorectic effect in 24-h food-deprived rats. These results suggest that the histaminergic system in involved in transduction of IP amylin's inhibitory effect on feeding in rats....Continue Reading

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Citations

Jun 14, 2002·Physiology & Behavior·E Del PreteE Scharrer
Apr 24, 2001·Pharmacology & Therapeutics·J C ClaphamM Tadayyon
Jul 4, 1998·Trends in Pharmacological Sciences·R LeursH Timmerman
Mar 12, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Elizabeth G Mietlicki-BaaseMatthew R Hayes
May 10, 2000·Clinical Neuropharmacology·B H Harvey, C D Bouwer
Dec 24, 2011·Cellular and Molecular Life Sciences : CMLS·Thomas A Lutz
Feb 7, 2012·Brain Research·Rohit SethJ Michael Overton
Mar 17, 2010·Physiology & Behavior·Catarina Soares Potes, Thomas Alexander Lutz
Nov 20, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Chao DengXu-Feng Huang
Nov 13, 2009·Journal of Animal Physiology and Animal Nutrition·J-Y SunX-Y Weng
Jul 22, 2014·The European Journal of Neuroscience·Fiona E BraeggerChristina N Boyle
Feb 1, 2014·Physiology & Behavior·Elizabeth G Mietlicki-Baase, Matthew R Hayes
Feb 24, 2006·Advances in Pharmacology·Andrew Young
Sep 25, 2010·The Journal of Pharmacology and Experimental Therapeutics·Maria Beatrice PassaniFernando Torrealba
Jun 17, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Thomas A Lutz
Oct 20, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A MolletE Scharrer
May 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T A LutzE Scharrer

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