PMID: 2715621Mar 1, 1989Paper

The histoautoradiographic localization of taurocholate in rat liver after bile duct ligation. Evidence for ongoing secretion and reabsorption processes

Journal of Hepatology
H P BuscherW Gerok

Abstract

To determine whether in complete obstructive cholestasis taurocholate is taken up by hepatocytes and if so whether it is secreted into bile, tritium-labelled taurocholate was localized by histoautoradiography on cryoslices from normal rat livers and from those after bile duct ligation. In non-cholestatic livers the hepatocytes of acinar zones 1 as well as the lumina and the epithelia of bile ductules and ducts became intensely labelled directly after injection of [3H]taurocholate into a mesenterial vein. Four hours and 4 days after bile duct ligation, hepatocytes of all three acinar zones became labelled, but in contrast to the normal state, pericanalicular concentration of silver grains was not observed, not even within 5 min. Fifteen days after bile duct obstruction, cryoslices taken 2 min after injection of [3H]taurocholate exhibited an intense silver grain labelling of all acinar zones, with the highest density at bile canalicular areas of the liver cell plates as well as the proliferated bile ductules and bile ducts. The biliary epithelium of small bile ductules and ducts of non-cholestatic and of bile duct-obstructed livers were also covered with silver grains; the epithelium of larger ducts exhibited significant labellin...Continue Reading

References

May 1, 1985·Scandinavian Journal of Gastroenterology·J T HolmbergI Ihse
Nov 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A L JonesB J Underdown
Jan 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P R HarmatzK J Bloch
Feb 1, 1974·The Journal of Clinical Investigation·P Guzelian, J L Boyer

❮ Previous
Next ❯

Citations

Dec 9, 2003·Trends in Molecular Medicine·Marco Arrese, Michael Trauner
Mar 23, 2000·Journal of Hepatology·G A Kullak-UblickG Paumgartner
Jul 29, 1999·Journal of Hepatology·M TraunerJ L Boyer
Dec 21, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·G J HooiveldM Müller
May 1, 1992·Journal of Gastroenterology and Hepatology·V J Desmet
Oct 5, 2007·Journal of Gastroenterology and Hepatology·Norihito WatanabeM James Phillips
Jun 16, 1999·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·E A Rodriguez-GarayG P Rodriguez
Jan 1, 1991·Progress in Histochemistry and Cytochemistry·A OchsW Gerok
Jul 1, 1995·Pathology, Research and Practice·V DesmetP Van Eyken
Oct 26, 1999·Journal of Gastroenterology and Hepatology·M TraunerR E Stauber
Jul 9, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Manuela GattoDomenico Alvaro
Feb 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B StollD Häussinger
Mar 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H P BuscherW Gerok
Jun 15, 2006·World Journal of Gastroenterology : WJG·Xuefeng XiaGene LeSage
Jan 31, 2002·World Journal of Gastroenterology : WJG·C StancaG A Kullak-Ublick
Mar 7, 2001·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·G J HooiveldM Müller
Mar 10, 2001·Clinics in Liver Disease·G A Kullak-Ublick, P J Meier

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.