PMID: 3756792Oct 15, 1986Paper

The histogenesis of adenocarcinoma of the gallbladder

Cancer
G P Dowling, J K Kelly

Abstract

A prospective study of 277 cholecystectomy specimens for evidence of isolated epithelial dysplasia of gallbladder mucosa is presented. In addition, 15 cases of primary adenocarcinoma of the gallbladder are retrospectively reviewed with particular reference to the presence of metaplasia and dysplasia adjacent to the infiltrating tumor, in order to establish the relationship between metaplasia, isolated epithelial dysplasia, and adenocarcinoma of the gallbladder. Only one case of isolated epithelial dysplasia was found in the 277 cholecystectomy specimens, and this arose within focal incomplete intestinal metaplasia. In the 15 cases of adenocarcinoma of the gallbladder, benign antral and/or incomplete intestinal metaplasia was found adjacent to the tumor in 11 cases. In 10 cases, dysplasia of this metaplastic epithelium was found in continuity with the tumor. The authors conclude that the most common pathway to adenocarcinoma is via dysplasia of metaplastic gallbladder epithelium.

References

Jul 1, 1978·American Journal of Clinical Pathology·R C HaggittH Colcher
Mar 11, 1975·Southern Medical Journal·B A BivinsW O Griffen
Feb 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·K Kowalewski, E F Todd
Jan 1, 1982·Human Pathology·P W Brandt-RaufS Adelson
Aug 1, 1983·Pathology, Research and Practice·M Laitio
May 1, 1984·The American Journal of Surgical Pathology·J Albores-SaavedraD E Henson
Nov 15, 1982·Cancer·S KozukaK Hachisuka

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Citations

Jan 3, 2001·Journal of Surgical Oncology·S W KimY H Park
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·M YamamotoE Tahara
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·S NakajoE Tahara
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·S NakajoE Tahara
Jan 16, 2014·Indian Journal of Surgical Oncology·Imran KhanRuchira Das
Nov 15, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wenjun WangXiong-ying Miao
May 23, 2002·The American Journal of Surgical Pathology·Hee Jin ChangWoo Ho Kim
Jul 21, 2004·Pathology International·Hee Jin ChangWoo Ho Kim
Jan 1, 1991·Ultrastructural Pathology·A KogaT Makino
May 28, 2013·Cirugía española·Helmut Alfredo Segovia Lohse, Osmar Manuel Cuenca Torres
Apr 6, 2013·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Lian-Wen YuanZhu-Lin Yang
Oct 1, 1989·Pathology, Research and Practice·M YamamotoE Tahara
Dec 8, 2011·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Yi-Lei DengXian-Ze Xiong
Apr 1, 1988·Pathology, Research and Practice·J Albores-SaavedraA Angeles-Angeles
Jun 1, 1990·Pathology, Research and Practice·V FrancoG Campesi
Jan 1, 2013·ISRN Radiology·Abhishek VijayakumarB S Shivaswamy
May 26, 2006·Journal of Surgical Oncology·Iván RoaJuan Roa
May 26, 2006·Journal of Surgical Oncology·Angelica A Saetta
Oct 4, 2011·Diagnostic Cytopathology·Dong-Cai Liu, Zhu-Lin Yang
Mar 17, 2016·Biochimica Et Biophysica Acta·Jaime A EspinozaJuan C Roa
Mar 1, 1989·Japanese Journal of Cancer Research : Gann·H Yamagiwa
May 16, 2003·Pathology, Research and Practice·Daniela CabibiFederico Aragona
Jun 21, 2005·Experimental and Molecular Pathology·Angelica A SaettaEfstratios Patsouris
Jul 21, 2011·International Journal of Surgery·Muhammad Rizwan KhanRizwan Azami
Jan 26, 2010·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Sung Joo JungSang Yong Choi
Jul 10, 2014·Journal of Clinical Pathology·Stefano Serra
Oct 15, 2008·São Paulo Medical Journal = Revista Paulista De Medicina·José Eduardo Vasconcelos FernandesSansom Henrique Bromberg
Apr 10, 1999·Journal of Gastroenterology and Hepatology·E Kyriacou
Sep 12, 2018·Surgical Endoscopy·Sarah Z WennmackerIris D Nagtegaal
Sep 15, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Rehan RaisDeyali Chatterjee
Feb 25, 1998·Cancer Investigation·D C MaibencoH O Douglass
Mar 2, 2005·Archives of Pathology & Laboratory Medicine·Sanjay Mukhopadhyay, Steve K Landas

❮ Previous
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