The histologic characteristics of primary and restenotic carotid plaque

The Journal of Surgical Research
J M MarekG C Hunter

Abstract

Although smooth muscle cell proliferation is a prominent feature of restenosis in experimental models, the role of cellular proliferation in the initiation and progression of carotid restenosis is not well documented. Between 1985 and 1995, 35 carotid endarterectomies (CEA) in 34 patients were performed for restenosis. Patient risk factors, cerebrovascular symptoms, and operative findings were recorded. Tissue specimens from 29 of these cases and 14 original specimens from the same patient were examined by light microscopy (H&E, trichrome, elastochrome, and Alcian blue) and immunohistochemistry (alpha actin, CD 68, vWF, and proliferating nuclear cell antigen (PCNA)) in order to determine the morphologic characteristics and cellular proliferative activity of the plaque. Hemodynamically significant recurrent stenosis occurred in the 29 patients (69% symptomatic) between 2 months and 30 years after their initial CEAs. Eleven of 29 (38%) lesions were removed early (< 3 years). Recurrent lesions were characterized based on their components as neointimal thickening, 24% (7/29), neointimal thickening and atherosclerosis, 55% (16/29), or atherosclerotic, 21% (6/29). Nineteen of 29 (66%) plaques were complicated by mural thrombus or int...Continue Reading

References

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Citations

Jan 10, 2014·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Alistair C LindsayRobin P Choudhury
Jan 5, 2013·The British Journal of Surgery·K BekelisN Labropoulos
Feb 8, 2005·Vascular and Endovascular Surgery·Christos D Liapis, Kosmas I Paraskevas
May 15, 2003·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·N KoshimaeK Nagata
Mar 5, 2010·Therapeutic Advances in Cardiovascular Disease·S D PatelA Smith
Apr 18, 2002·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Pierre AlricCharles Marty-Ané

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