The histological prevalence and clinical implications of folliculotropism and syringotropism in mycosis fungoides

Chinese Clinical Oncology
Claudia HossainJoya Sahu

Abstract

Mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma, remains a challenge for clinicians to stage and manage. Classically, MF is determined through histopathologic evidence of a neoplastic infiltrate within the epidermis. In certain patients, however, the infiltrate extends into the hair follicles and sweat glands. The objective of this study is to determine the utility of expanding the analysis of histopathology reports to include the reporting of folliculotropism and syringotropism. This is a prospective, observational study conducted in a single facility from 2012-2018. All patients with MF, excluding those treated at this facility for less than six months with the exception of those with incomplete pruritus documentation, or absence of initial biopsy analysis were studied. Modified severity weighted assessment tool (mSWAT) quantified body surface area and treatments attempted per patient were continuously charted. Patients were surveyed for presence and degree of pruritus and pain. Evaluation of these parameters were charted at the initial patient visit and correlated with their primary biopsy for presence or absence of folliculotropism and syringotropism. Of the 87 patients examined, 70 patients (80%) ...Continue Reading

Citations

Jun 12, 2021·Indian Journal of Dermatology, Venereology and Leprology·Bruno Castro SouzaJosé Antonio Sanches

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