The histological spectrum of chronic necrotizing forms of pulmonary aspergillosis

Human Pathology
S A Yousem

Abstract

Chronic necrotizing pulmonary aspergillosis (CNPA) is a rare locally destructive form of chronic aspergillosis that is recognized as a clinical syndrome, but has been poorly defined histologically. In this study, 10 cases of CNPA were evaluated from a morphological perspective. Three distinct forms of CNPA emerged. One form (n = 4) resembled a necrotizing granulomatous pneumonia centered around a central zone of infarct-like necrosis of parenchyma resulting from angioinvasive aspergillus. The second pattern (n = 4) was that of a granulomatous bronchiectatic cavity with a central fungus ball and subtle tongues of necrosis and inflammation extending into and through the fibrous wall of the cavity. A final form (n = 2) had a bronchocentric granulomatosis-like appearance with a necrotizing granulomatous bronchitis/bronchiolitis associated with luminal necrotic debris and replacement of mucosa by a palisaded histiocytic reaction. Despite the varied histomorphology, all patients survived the aspergillus infection after antifungal therapy and surgical resection. The different forms of pulmonary aspergillosis are briefly discussed, and the differential diagnosis, with particular regard to mycetomas and allergic forms of bronchocentric ...Continue Reading

References

Jul 1, 1990·Southern Medical Journal·M R BennettP C Fiehler
Jul 1, 1989·Chest·H D TazelaarC R Smith
May 1, 1986·Chest·M S IpC K Mok
May 1, 1986·The American Journal of Surgical Pathology·J L Myers, A L Katzenstein
Oct 1, 1986·Pathology, Research and Practice·V Tron, A Churg
Jan 1, 1973·The American Journal of Medicine·R D MeyerB Yu
Mar 1, 1970·Medicine·R C YoungV T DeVita
Jul 1, 1968·British Journal of Diseases of the Chest·P O Leggat, D M De Kretser
Mar 1, 1967·Diseases of the Chest·K O Husebye
Oct 1, 1980·Cancer·C Przyjemski, R Mattii
Jul 1, 1981·Human Pathology·M N KossL Hochholzer
Mar 1, 1980·The American Journal of Medicine·J L HargisF C Hiller
Jul 1, 1994·Respiratory Medicine·C N Grahame-ClarkeD W Empey
Apr 1, 1961·British Journal of Diseases of the Chest·A SALIBAO A BEATTY
Jul 1, 1963·American Journal of Clinical Pathology·J H SEABURY, M SAMUELS
Mar 1, 1963·Annals of Internal Medicine·H W WAHNERL A WEED

❮ Previous
Next ❯

Citations

Feb 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S J LinS M Teutsch
Jan 26, 2010·Transplantation·Aniket VadnerkarM Hong Nguyen
Apr 13, 2011·Clinical Microbiology Reviews·Jeannette Guarner, Mary E Brandt
Aug 2, 2003·Journal of Clinical Pathology·A CavazzaG Rossi
Jan 18, 2005·Chest·Lakshmi Kumari YellaVirgilio Gillego
Jul 15, 2015·Japanese Journal of Infectious Diseases·Tsunehiro AndoKazutoshi Shibuya
Apr 21, 2009·Clinics in Chest Medicine·Brent P Riscili, Karen L Wood
Apr 10, 2015·Medical Mycology Journal·Takayoshi Tashiro
Jan 30, 2007·Histopathology·O A El-Zammar, A-L A Katzenstein
May 10, 2006·British Journal of Haematology·Ayalew TefferiAnimesh Pardanani
Dec 13, 2012·Annals of the New York Academy of Sciences·Koichi IzumikawaShigeru Kohno
Jul 29, 2005·Pathology, Research and Practice·Uğur Pabuççuoğlu
Sep 22, 2001·The Annals of Thoracic Surgery·S EndoS Yamamoto
Dec 19, 2013·Mediators of Inflammation·Naobumi TochigiKazutoshi Shibuya
Mar 21, 2015·European Radiology·S R DesaiD M Hansell
Sep 4, 2015·Diagnostic Pathology·Naobumi TochigiKazutoshi Shibuya
Aug 8, 2002·The Korean Journal of Internal Medicine·Doh Hyung KimKye Young Lee
Mar 4, 2000·AJR. American Journal of Roentgenology·S Y KimS J Kim
Oct 12, 2011·Pharmacology·Friederike TraunmüllerChristian Joukhadar
Jun 15, 2004·The Pediatric Infectious Disease Journal·Kevin G RagostaJoseph B Domachowske
Jan 1, 2014·Infection and Immunity·Lauren M LillyChad Steele
Jun 2, 2005·Cancer·Igal LeibovitchRobert Paver
Jan 18, 2005·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Fengshi ChenKoji Chihara
Sep 10, 2010·Current Opinion in Infectious Diseases·Koichi IzumikawaShigeru Kohno
Aug 23, 2005·Medical Mycology·R Greene
Mar 9, 2002·Journal of Computer Assisted Tomography·Michael B GotwayW Richard Webb
Aug 23, 2005·Medical Mycology·W W HopeD W Denning
Jun 7, 2016·Journal of Fungi·Gemma E Hayes, Lilyann Novak-Frazer
Jan 11, 2014·The Clinical Respiratory Journal·Boubou CamaraUNKNOWN Grenoble Aspergillus Committee
Sep 4, 2018·Frontiers in Microbiology·Takahiro Takazono, Koichi Izumikawa
May 6, 2010·Archives of Pathology & Laboratory Medicine·Sanjay Mukhopadhyay, Anthony A Gal
May 6, 2010·Archives of Pathology & Laboratory Medicine·Timothy Craig Allen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Related Papers

Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases
Nobuaki MamesayaEiji Katsuyama
Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes
P M Logan, N L Müller
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
Yu-long ZhengJian-ying Zhou
© 2021 Meta ULC. All rights reserved