The histone acetyltransferase Myst2 regulates Nanog expression, and is involved in maintaining pluripotency and self-renewal of embryonic stem cells

FEBS Letters
Min Seong KimYeun Kyu Jang

Abstract

The histone acetyltransferase Myst2 plays an important role in embryogenesis, but its function in undifferentiated ES cells remains poorly understood. Here, we show that Myst2 plays a role in pluripotency and self-renewal of ES cells. Myst2 deficiency results in loss of characteristic morphology, decreased alkaline phosphatase staining and reduced histone acetylation, as well as aberrant expression of pluripotency and differentiation markers. Our ChIP data reveal a direct association of Myst2 with the Nanog promoter and Myst2-dependent Oct4 binding on the Nanog promoter. Together our data suggest that Myst2-mediated histone acetylation may be required for recruitment of Oct4 to the Nanog promoter, thereby regulating Nanog transcription in ES cells.

References

Aug 7, 1999·The Journal of Biological Chemistry·M Iizuka, B Stillman
Aug 10, 2000·The Journal of Biological Chemistry·M SharmaZ Sun
Mar 30, 2001·The Journal of Biological Chemistry·T W BurkeJ R Nevins
May 15, 2002·Current Biology : CB·Aurélie GrienenbergerJacques Pradel
Apr 30, 2005·The Journal of Biological Chemistry·David J RoddaPaul Robson
Mar 30, 2006·Nature Cell Biology·Véronique AzuaraAmanda G Fisher
May 26, 2006·Nature Reviews. Molecular Cell Biology·Eran Meshorer, Tom Misteli
Sep 26, 2006·Biochemical and Biophysical Research Communications·Romuald ContzlerMarcel Huber
Apr 3, 2007·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Satoru KobayakawaKuniya Abe
Apr 19, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Wenchu LinSharon Y R Dent
Jun 5, 2007·Nature Protocols·David ShechterSandra B Hake
Jul 5, 2007·Journal of Bioscience and Bioengineering·Hiroshi Kurosawa
Nov 3, 2007·Genes & Development·Hitoshi Niwa
Feb 12, 2008·Nature Cell Biology·Jianming JiangHuck-Hui Ng
May 9, 2008·Cell Stem Cell·Sol EfroniEran Meshorer
Jul 26, 2008·Journal of Cell Science·Silvia ParisiTommaso Russo
Oct 25, 2008·Cell Cycle·Thomas G FazzioBarbara Panning
Jan 20, 2009·The Journal of Biological Chemistry·Xiaomin Zhong, Ying Jin
Sep 10, 2009·Nature Reviews. Molecular Cell Biology·Ben D MacarthurIhor R Lemischka
Sep 2, 2010·Cell Stem Cell·Keriayn N SmithStephen Dalton
Sep 30, 2010·BMC Biology·Pierre-Yves Bourillot, Pierre Savatier
Dec 15, 2010·Molecular and Cellular Biology·Andrew J KuehTim Thomas
Mar 19, 2011·Cell·Richard A Young
Jun 15, 2011·Cell·Stuart H Orkin, Konrad Hochedlinger
Mar 30, 2012·Stem Cells and Development·Yun Hwa LeeQiang Wu
Sep 26, 2013·Genes & Development·Marie-Eve LalondeJacques Côté
Dec 5, 2013·ELife·Poshen B ChenThomas G Fazzio

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Citations

Jun 2, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Jina LeeYeun Kyu Jang
Jan 5, 2019·The Journal of Reproduction and Development·Ngan Thi Kim HoHong-Thuy Bui
Aug 5, 2017·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Masayoshi IizukaTomoki Okazaki
Oct 8, 2018·Nature Reviews. Cancer·Zbyslaw SondkaSimon A Forbes
May 28, 2021·Cell Death & Disease·Wenhui ZhongYubin Liu
Jun 3, 2021·Cancers·Ruicen HeKarl Riabowol
Jul 15, 2021·Nucleic Acids Research·Yanhui XiaoJiemin Wong

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