The histone deacetylase Hos2 forms an Hsp42-dependent cytoplasmic granule in quiescent yeast cells.

Molecular Biology of the Cell
I-Chun LiuJun-Yi Leu

Abstract

One of many physiological adjustments in quiescent cells is spatial regulation of specific proteins and RNA important for the entry to or exit from the stationary phase. By examining the localization of epigenetic-related proteins in Saccharomyces cerevisiae, we observed the formation of a reversible cytosolic "stationary-phase granule" (SPG) by Hos2, a nuclear histone deacetylase. In the stationary phase, hos2 mutants display reduced viability. Additionally, they exhibit a significant delay when recovering from stationary phase. Hos2 SPGs also contained Hst2, a Sir2 homologue, and several stress-related proteins, including Set3, Yca1, Hsp26, Hsp42, and some known components of stress granules. However, Hos2 SPG formation does not depend on the formation of stress granules or processing bodies. The absence or presence of glucose is sufficient to trigger assembly or disassembly of Hos2 SPGs. Among the identified components of Hos2 SPGs, Hsp42 is the first and last member observed in the Hos2 SPG assembly and disassembly processes. Hsp42 is also vital for the relocalization of the other components to Hos2 SPGs, suggesting that Hsp42 plays a central role in spatial regulation of proteins in quiescent cells.

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Citations

Oct 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Charis PutinskiLynn A Megeney
Nov 20, 2013·The Journal of Cell Biology·Damien LaporteIsabelle Sagot
Jul 1, 2015·The Journal of Cell Biology·Damien LaporteIsabelle Sagot
May 22, 2013·The Journal of Cell Biology·Lee Zeev PetersShay Ben-Aroya
Oct 30, 2015·Briefings in Functional Genomics·Michael Downey, Kristin Baetz
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May 11, 2017·Annual Review of Biochemistry·Emily Mitchell SontagJudith Frydman
Jan 25, 2018·The Journal of Cell Biology·Tomas GrouslAxel Mogk
Sep 12, 2013·The Journal of Biological Chemistry·Colin W MacDiarmidDavid J Eide
Jan 4, 2019·Journal of Cell Science·Isabelle Sagot, Damien Laporte
May 16, 2019·Annual Review of Microbiology·Axel MogkBernd Bukau
Jan 31, 2020·Frontiers in Molecular Biosciences·Ofri Karmon, Shay Ben Aroya
Jul 8, 2020·International Journal of Molecular Sciences·Karamat MohammadVladimir I Titorenko
Oct 11, 2020·Current Genetics·Safia Mahabub SautyKrassimir Yankulov

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