The histone demethylase KDM6B in the medial prefrontal cortex epigenetically regulates cocaine reward memory

Neuropharmacology
Yu-Xiang ZhangYan-Chun Li

Abstract

Epigenetic remodeling contributes to synaptic plasticity via modification of gene expression, which underlies cocaine-induced long-term memory. A prevailing hypothesis in drug addiction is that drugs of abuse rejuvenate developmental machinery to render reward circuitry highly plastic and thus engender drug memories to be highly stable. Identification and reversal of these pathological pathways are therefore critical for cocaine abuse treatment. Previous studies revealed an interesting finding in which the mRNA of histone lysine demethylase, KDM6B, is upregulated in the medial prefrontal cortex (mPFC) during early cocaine withdrawal. However, whether and how it contributes to drug-seeking behavior remain unknown. Here we used a conditioned place preference paradigm to investigate the potential role of KDM6B in drug-associated memory. We found that KDM6B protein levels selectively increased in the mPFC during cocaine withdrawal. Notably, systemic injection of KDM6B inhibitor, GSK-J4, disrupted both reconsolidation of cocaine-conditioned memory and cocaine-primed reinstatement, suggesting dual effects of KDM6B in cocaine reward memory. In addition, we found that NMDAR expression and function were both enhanced during early cocain...Continue Reading

References

Jun 12, 2001·Current Opinion in Neurobiology·S Cull-CandyM Farrant
Dec 26, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yossef Itzhak, Julio L Martin
Jan 22, 2003·Trends in Neurosciences·Karim Nader
Dec 3, 2005·European Journal of Pharmacology·Heath D SchmidtR Christopher Pierce
Dec 29, 2005·Proceedings of the National Academy of Sciences of the United States of America·Amir A LevineJames H Schwartz
Nov 16, 2007·The European Journal of Neuroscience·Fabio FumagalliMarco Andrea Riva
Nov 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sunhwa HongKai Ge
Oct 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Huaixing WangWen-Jun Gao
Jul 18, 2009·Neuron·Yanhua H HuangYan Dong
Aug 5, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Mei QiangJi Li
Sep 13, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Melissa A SnyderWen-Jun Gao
Jan 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Amy L MiltonBarry J Everitt
May 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Cassandra D GipsonPeter W Kalivas
Apr 25, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·James M OtisDevin Mueller
Jun 25, 2014·Trends in Pharmacological Sciences·Yan Dong, Eric J Nestler
Aug 19, 2014·Nature·Panagiotis NtziachristosIannis Aifantis
Oct 4, 2014·Nature·Bo HeinemannKristian Helin
Feb 26, 2015·Nucleic Acids Research·Beatrice RondinelliGiovanni Tonon
Apr 2, 2015·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Yanhua H HuangYan Dong
May 6, 2015·Nature Medicine·Catherine S GrassoMichelle Monje
May 30, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Arthur GodinoJean Lud Cadet
Jul 6, 2015·Neuroscience and Biobehavioral Reviews·Sarah A MonacoWen-Jun Gao
Jul 21, 2015·The International Journal of Biochemistry & Cell Biology·Jana S BurchfieldRong-Fu Wang
May 31, 2016·Nature Neuroscience·Nicholas M GrazianeYan Dong
Jun 30, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bo XingWen-Jun Gao
Sep 30, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Isabel F AugurJamie Peters
Oct 27, 2016·Annals of Neurosciences·Ashok JangraMangala Lahkar
Feb 1, 2017·Neuropharmacology·Angelo ContarinoPier-Vincenzo Piazza
Mar 21, 2017·Annals of the Rheumatic Diseases·Jun DaiHongwei Ouyang
Apr 8, 2017·Science·Takashi KitamuraSusumu Tonegawa

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Citations

Mar 17, 2020·Cellular and Molecular Life Sciences : CMLS·Brooke N Bender, Mary M Torregrossa
Oct 18, 2020·Biological Psychiatry·Craig T WernerXuan Li
Feb 19, 2021·Pharmacology & Therapeutics·Xiaohang CheChunfu Wu

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