The Histone Methyltransferase Gene Absent, Small, or Homeotic Discs-1 Like Is Required for Normal Hox Gene Expression and Fertility in Mice

Biology of Reproduction
Michelle L BrinkmeierSally A Camper

Abstract

Chromatin remodeling influences gene expression in developing and adult organisms. Active and repressive marks of histone methylation dictate the embryonic expression boundaries of developmentally regulated genes, including the Hox gene cluster. Drosophila ash1 (absent, small or homeotic discs 1) gene encodes a histone methyltransferase essential for regulation of Hox gene expression that interacts genetically with other members of the trithorax group (TrxG). While mammalian members of the mixed lineage leukemia (Mll) family of TrxG genes have roles in regulation of Hox gene expression, little is known about the expression and function of the mammalian ortholog of the Drosophila ash1 gene, Ash1-like (Ash1l). Here we report the expression of mouse Ash1l gene in specific structures within various organs and provide evidence that reduced Ash1l expression has tissue-specific effects on mammalian development and adult homeostasis. Mutants exhibit partially penetrant postnatal lethality and failure to thrive. Surviving mutants have growth insufficiency, skeletal transformations, and infertility associated with developmental defects in both male and female reproductive organs. Specifically, expression of Hoxa11 and Hoxd10 are altered ...Continue Reading

References

Nov 9, 1968·Nature·D G Whittingham
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·W C SkarnesR S Beddington
Aug 1, 1994·Veterinary Parasitology·H Zahner
Dec 1, 1993·Current Opinion in Cell Biology·R Paro
Jan 1, 1996·Experimental Animals·H SuzukiJ Adachi
Jan 15, 1997·Developmental Biology·F Chen, M R Capecchi
Aug 1, 1997·Current Opinion in Genetics & Development·A Gould
Apr 20, 1999·International Review of Cytology·C Kirchhoff
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·T NakamuraE Canaani
Jan 21, 2003·Biology of Reproduction·Daniela BomgardnerTerry T Turner
Sep 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Kristin Nastase Byrd, Allen Shearn
Jul 24, 2004·Animal Reproduction Science·J-L GattiJ-L Dacheux
Nov 24, 2004·The International Journal of Developmental Biology·James D Zieske
Feb 17, 2005·Seminars in Reproductive Medicine·Rodrigo Fernandez-ValdiviaJohn P Lydon
Jul 13, 2006·Annals of the New York Academy of Sciences·Aster H JuanFrank H Ruddle
Aug 1, 2006·Nature Structural & Molecular Biology·Yali DouRobert G Roeder
Sep 19, 2006·Molecular and Cellular Biology·Heidi G SutherlandWendy A Bickmore
Dec 15, 2006·Biology of Reproduction·Scott A JelinskyDaniel S Johnston
Jul 13, 2007·Development·Daniel C McIntyreDeneen M Wellik
Oct 10, 2007·Molecular and Cellular Biology·Gregory D GregoryGerd A Blobel
Mar 29, 2008·Cell Stem Cell·Kathryn A McMahonHugh J M Brady
Jul 5, 2008·Cancer Cell·Akihiko Yokoyama, Michael L Cleary
Dec 3, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jeongkyung LeeJae W Lee
Mar 7, 2009·Methods in Molecular Biology·Thomas Doetschman
Nov 7, 2009·Seminars in Cell & Developmental Biology·Mareike Albert, Kristian Helin
Nov 19, 2009·Molecular Reproduction and Development·Sanjoy K Das
Mar 20, 2010·The FEBS Journal·Khairul I Ansari, Subhrangsu S Mandal
May 21, 2010·Biology of Reproduction·Jae-Wook JeongFrancesco J DeMayo
Jul 24, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Elizabeth M SnyderBarry T Hinton
Oct 28, 2011·Molecular Reproduction and Development·Mariano G BuffoneGeorge L Gerton
Apr 5, 2012·Nature Reviews. Genetics·Eric L Greer, Yang Shi
Feb 15, 2013·Biology of Reproduction·Justyna Filant, Thomas E Spencer
Apr 27, 2013·Molecular Human Reproduction·Paul S CookeKanako Hayashi
Sep 21, 2013·Journal of Assisted Reproduction and Genetics·Koji Yoshinaga

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Citations

Apr 11, 2017·American Journal of Medical Genetics. Part a·Nobuhiko OkamotoKenjiro Kosaki
Nov 30, 2018·Nature Communications·Ilaria CastiglioniDavide Gabellini
Nov 2, 2019·Molecular Psychiatry·Shiguo LiuJi-Song Guan
Dec 2, 2020·Developmental Neurobiology·Cheng ZhangFengyuan Che
May 16, 2021·Nature Communications·David S RogawskiJolanta Grembecka

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