The histopathology of myeloma in the bone marrow

Journal of Clinical and Experimental Hematopathology : JCEH
Masahiko Fujino

Abstract

Myeloma is characterized by the neoplastic proliferation of monoclonal plasma cells. A diagnosis of myeloma is based on the criteria proposed by the International Myeloma Working Group and the pathological findings.Myeloma cells are classified into four types: mature, immature, pleomorphic, and plasmablastic. There are three patterns in which myeloma infiltrates bone marrow - nodular, interstitial, and diffuse. Dutcher bodies are highly specific to neoplastic myeloma cells. On immunohistochemical staining, the specificity of CD138 is high for plasma cells. As a clear image is often not obtained from the immunohistochemical staining of the immunoglobulin light chain, in situ hybridization is recommended. Abnormal expression of CD56 is seen in 70-80% of cases by flow cytometry analysis. CD56 expression definitively indicates myeloma, suggesting its high diagnostic value. Evaluation of the infiltration pattern, monoclonality, and abnormal antigen expression of plasma cells is more important than the plasmocytic ratio to determine whether a case is reactive or neoplastic.Multiple gene abnormalities function in the onset and progression of myeloma. In our department, we analyze CCND1, FGFR3, MAF, and del (17p13) by FISH for all myel...Continue Reading

References

Oct 3, 2009·Leukemia·R FonsecaUNKNOWN International Myeloma Working Group
Nov 30, 2010·Best Practice & Research. Clinical Haematology·Shaji KumarWilliam Morice
Jan 15, 2011·Seminars in Hematology·Adriana Zingone, W Michael Kuehl
Oct 2, 2012·The Journal of Clinical Investigation·W Michael Kuehl, P Leif Bergsagel
Mar 5, 2013·International Journal of Hematology·Marta Chesi, P Leif Bergsagel
Dec 3, 2014·The Lancet Oncology·S Vincent RajkumarJesus F San Miguel

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Citations

Dec 6, 2018·Clinical Nuclear Medicine·Zhanli FuQian Li
Feb 2, 2021·Curēus·Anshu WadehraManmeet M Singh
Mar 10, 2021·Skeletal Radiology·Megan J FitzpatrickAliyah R Sohani

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