The history of pancreas transplantation: past, present and future

Acta chirurgica Belgica
J-P SquiffletDavid E R Sutherland

Abstract

The first attempt to cure type 1 diabetes by pancreas transplantation was done at the University of Minnesota, in Minneapolis, on December 17, 1966, followed by a series of whole pancreas transplantation. Due to the lack of potent immunosuppressive drugs, rejections and infections, it was concluded that pancreas was less antigenic than the kidney which was less antigenic than the duodenum. It opened the door to a period, between the mid 70's to mid 80's where only segmental pancreatic grafts were used in the recipient. Numerous techniques for diverting or dealing with the pancreas juice secretion were described, none of them being satisfactory. In the late 70's - early 80's, three major events happened and boosted the development of pancreas transplantation: firstly the introduction of Cyclosporine A in the clinical field, secondly the organization on March 1980, of the first international meeting on Pancreas Transplantation with the first report of the International Pancreas Transplantation Registry (IPTR) and finally in 1982, the organization of the first informal so-called Spitzingsee meetings where pancreas transplantation successes but mainly failures were discussed which precluded the onset of IPITA (International Pancrea...Continue Reading

Citations

Feb 25, 2011·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Luis H Toledo-Pereyra, David E R Sutherland
Sep 8, 2012·Regenerative Medicine·Jennifer M ChhounMeri T Firpo
May 18, 2011·Journal of Intensive Care Medicine·Joseph R Scalea, Matthew Cooper
Jul 4, 2020·Current Opinion in Organ Transplantation·Julien BranchereauRutger Ploeg
Mar 9, 2017·Current Diabetes Reports·Bassem F Salama, Gregory S Korbutt
May 29, 2018·Journal of Medical Imaging and Radiation Oncology·Paula Gallego Ferrero, Juan Crespo Del Pozo
Dec 5, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Thomas PrudhommeJulien Branchereau
Jun 3, 2021·International Journal of Molecular Sciences·Thomas PrudhommeJulien Branchereau

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