Oct 1, 1979

The history of the A family of inbred mice and the biology of its congenital malformations

Teratology
H Kalter

Abstract

The A family of inbred mice which originated in 1921, came during its early development to have incorporated into its genome the tendency to several congenital malformations, among them cleft lip and palate. These sporadic abnormalities are of interest because they closely resemble their human counterparts in morphology and development, and because they share with them a multifactorial basis. The origins and development of the A family are traced, and the abnormalities are described and the forces affecting them detailed.

Mentioned in this Paper

Litter Size
Congenital Neurologic Anomalies
Science of Morphology
Inbred Strain
Carcinomatosis
Cleft Palate, Isolated
Conditions, Recessive Genetic
Teratogens
Cleft Palate With Cleft Lip
Sib Mating

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.