PMID: 7543368Aug 11, 1995Paper

The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

Cell
U FischerR Lührmann

Abstract

HIV-1 Rev protein directs nuclear export of pre-mRNAs and mRNAs containing its binding site, the Rev response element (RRE). To define how Rev acts, we used conjugates between bovine serum albumin (BSA) and peptides comprising the Rev activation domain (BSA-R). BSA-R inhibited Rev-mediated nuclear RNA export, whereas a mutant activation domain peptide conjugate did not. BSA-R did not affect the export of mRNA, tRNA, or ribosomal subunits, but did inhibit export of 5S rRNA and spliceosomal U snRNAs. BSA-R was itself exported from the nucleus in an active, saturable manner. Thus, the Rev activation domain constitutes a nuclear export signal that redirects RRE-containing viral RNAs to a non-mRNA export pathway.

References

Feb 20, 1992·Nature·S Piñol-Roma, G Dreyfuss
Sep 1, 1992·The Journal of Cell Biology·E IzaurraldeI W Mattaj
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A Khanna-Gupta, V C Ware
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B K FelberG N Pavlakis
Aug 14, 1986·Nature·D S GoldfarbR D Kornberg
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M Zasloff
Mar 1, 1994·The Journal of Cell Biology·A JarmolowskiI W Mattaj
Apr 21, 1995·Cell·E Izaurralde, I W Mattaj
Aug 24, 1995·Nature·E IzaurraldeI W Mattaj
Jul 1, 1994·Genes & Development·B E Meyer, M H Malim
Dec 16, 1994·Cell·M A Powers, D J Forbes
Feb 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·M BrayM L Hammarskjöld
Aug 13, 1993·Cell·M S Schmidt-ZachmannE A Nigg

❮ Previous
Next ❯

Citations

Jul 9, 1999·Reviews in Medical Virology·A Phelan, Barklie Clements J
Sep 23, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C Perez-TerzicD E Clapham
Dec 12, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M C Beckerle
Oct 12, 2000·Biochemical and Biophysical Research Communications·D WatanabeY Nishiyama
Apr 1, 1996·Journal of Biomedical Science·Y. XuF. Wong-Staal
Feb 6, 1999·Journal of Biomedical Science·K T BorgM Schmidt
Apr 1, 1999·Cell Biochemistry and Biophysics·D B DeFranco
Sep 12, 2012·Medical Microbiology and Immunology·Nadine FrankenbergBodo Plachter
Jun 19, 2009·Medical Molecular Morphology·Tominori KimuraHisao Yamada
Mar 10, 2006·Pharmaceutical Research·Marieke A E M van der AaDaan J A Crommelin
Nov 1, 1996·Trends in Genetics : TIG·B Chabot
Aug 5, 1996·Transfusion Science·S Joshi, R L Joshi
Aug 1, 1996·Trends in Cell Biology·U FischerG Dreyfuss
Jan 1, 1996·Trends in Microbiology·Y Yoneda
Oct 23, 2004·Best Practice & Research. Clinical Haematology·Michel SadelainIsabelle Rivière
Dec 31, 2003·Trends in Genetics : TIG·James M Smith, Peter A Koopman
Dec 4, 2003·Experimental Cell Research·Séverine DemartRuth Brack-Werner
Jun 11, 2002·Biochemical and Biophysical Research Communications·Tomiyasu MurataNorio Kaneda
Jan 18, 2003·Experimental Cell Research·Megan Fabbro, Beric R Henderson
May 17, 2003·Experimental Cell Research·Mario KösterHansjörg Hauser
Apr 27, 2000·Progress in Biophysics and Molecular Biology·A S SobolevA A Rosenkranz
Jun 6, 2003·Advanced Drug Delivery Reviews·Joshua Z Gasiorowski, David A Dean
Jun 2, 1998·Biochimica Et Biophysica Acta·D M Koepp, P A Silver
Jun 1, 1996·Current Opinion in Cell Biology·N Panté, U Aebi
Jun 1, 1997·Current Opinion in Cell Biology·S Nakielny, G Dreyfuss
Jun 26, 1998·Current Opinion in Cell Biology·J E Dahlberg, E Lund
Apr 1, 1997·Current Opinion in Genetics & Development·M S Lee, P A Silver
May 17, 2001·Bioorganic & Medicinal Chemistry Letters·J B TokR C Des Jean
Nov 11, 1999·Current Biology : CB·A K Hopper
Nov 24, 2001·Trends in Cell Biology·S KuerstenI W Mattaj
Dec 1, 1996·Trends in Microbiology·Z Kiss-László, T Hohn
Nov 6, 2002·Trends in Biochemical Sciences·Arlen W JohnsonJames Dahlberg
Aug 23, 2003·Trends in Biochemical Sciences·Bryan R Cullen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.