The HIV-1 TAT protein induces the expression and extracellular appearance of acidic fibroblast growth factor.

The Journal of Biological Chemistry
S R OpalenikJ A Thompson

Abstract

Mounting experimental evidence suggests that the TAT protein, released from human immunodeficiency virus-1 (HIV-1)-infected inflammatory cells, may genetically reprogram targeted cells within a localized environment to develop highly vascularized tumors of mesenchymal origin. The fibroblast growth factor (FGF) family of polypeptides has gained general acceptance as initiators of angiogenesis and functions as potent mitogens for mesoderm-derived cells. To evaluate a potential biological relationship between TAT and acidic FGF (FGF-1), primary murine embryonic fibroblasts either were transfected with the viral transactivator or were transduced (retrovirally mediated) with a secreted, chimeric form of the human polypeptide growth factor, human stomach tumor/Kaposi's sarcoma (hst/KS)FGF-1. Reverse transcriptase-polymerase chain reaction, Western blotting, in situ immunohistochemical, heparin affinity, DNA synthesis, and transient transfection techniques were used to confirm expression, localization, and functionality of the transgenes. Both transfected and transduced cells constitutively expressing either TAT or (hst/KS)FGF-1 adopted a transformed phenotype, maintained aggressive growth behavior, and demonstrated both induction of ...Continue Reading

References

Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A JacksonT Maciag
Nov 16, 1992·Biochemical and Biophysical Research Communications·X ZhanT Maciag
Apr 11, 1992·Lancet·F J StaalL A Herzenberg
Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J P TaylorS Amini
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J JouanneauJ P Thiery
Jan 1, 1991·Advances in Experimental Medicine and Biology·B EnsoliR C Gallo
Jun 1, 1991·Microbiological Reviews·K Steffy, F Wong-Staal
Sep 1, 1991·American Journal of Respiratory Cell and Molecular Biology·L JornotA F Junod
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M B FeinbergA D Frankel
Jan 23, 1987·Science·J Folkman, M Klagsbrun
Jan 1, 1987·Nouvelle Revue Française D'hématologie·A Camez, G Tobelem
May 1, 1989·Molecular and Cellular Biology·R FrieselT Maciag
Jan 1, 1989·Annual Review of Biochemistry·W H Burgess, T Maciag
May 1, 1989·Somatic Cell and Molecular Genetics·K D AndersonW F Anderson
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A D FrankelC O Pabo
Jan 1, 1989·Molecular and Cellular Biology·D Martin-ZancaM Barbacid
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G P NolanL A Herzenberg
Jan 1, 1987·Annals of the New York Academy of Sciences·R Bajpai
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J HauberB R Cullen
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G BoucheF Amalric
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B J Wu, R I Morimoto
Nov 1, 1985·Annals of Internal Medicine·B SafaiB Dupont
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P E AuronC A Dinarello
Dec 5, 1982·Journal of Molecular Biology·C B Lawrence, K J Jackson

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Citations

Aug 12, 2000·Nuclear Medicine and Biology·K R ZinnJ A Thompson
Apr 20, 2001·The International Journal of Biochemistry & Cell Biology·F BussolinoB Ensoli
Oct 27, 1997·AIDS Research and Human Retroviruses·U CavallaroJ A Maier
Jul 30, 2002·The EMBO Journal·Camilla Skiple SkjerpenSjur Olsnes
Oct 5, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S S KelpkeJ A Thompson
Feb 23, 2000·Archives of Biochemistry and Biophysics·J ChoiH J Forman
Jun 21, 2001·Biochemical and Biophysical Research Communications·Y D SohnY Jang
Nov 1, 2003·Archives of Biochemistry and Biophysics·Patricia BagnascoJohn A Thompson
Feb 16, 2005·Journal of Neuroimmunology·Selvajothi AbrahamShohreh Amini
Mar 13, 1999·Biochemical Pharmacology·K WatsonR J Edwards
Jun 6, 2006·Journal of Neuroimmunology·Mazen B EldeenBassel E Sawaya
Jan 7, 1998·Journal of the American Academy of Dermatology·P Ruiz-AvilaJ M Ródenas
Nov 18, 2005·Nitric Oxide : Biology and Chemistry·Doanh C TranHo-Leung Fung
Mar 4, 2014·Journal of Thyroid Research·Rabia CherqaouiVinod Mody
Mar 20, 2003·FEMS Microbiology Letters·Claudio BrigatiAdriana Albini
Jan 11, 2001·FEBS Letters·M MariottiJ A Maier
Apr 25, 1997·The Journal of Biological Chemistry·M RusnatiM Presta
Oct 12, 2000·The Journal of Biological Chemistry·M TyagiM Giacca
Mar 15, 1996·Transplantation·S T ZeiglerJ A Thompson
Jun 5, 1996·Biochimica Et Biophysica Acta·J T ShinJ A Thompson
Feb 8, 2003·Archives of Biochemistry and Biophysics·Jing JiaoJohn A Thompson
Apr 25, 2006·Archives of Biochemistry and Biophysics·Pei ZhangJohn A Thompson

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