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The HIV protease inhibitor darunavir prevents kidney injury via HIV-independent mechanisms

Scientific Reports

Nov 1, 2019

Xiao-Bo GaoMichael Jordan Ross

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Abstract

HIV-associated nephropathy (HIVAN) is a rapidly progressive kidney disease that is caused by HIV infection of renal epithelial cells with subsequent expression of viral genes, including vpr. Antiretroviral therapy ameliorates HIVAN without eradicating HIV from the kidneys and the mechan...read more

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Genes
Genes, Viral
Genetic Vectors
HIV
HIV Infections
Kidney
Laboratory mice
Mice, Transgenic
Peptide Hydrolases
Protease Inhibitors
2
2
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The HIV protease inhibitor darunavir prevents kidney injury via HIV-independent mechanisms

Scientific Reports

Nov 1, 2019

Xiao-Bo GaoMichael Jordan Ross

PMID: 31676833

DOI: 10.1038/s41598-019-52278-3

Abstract

HIV-associated nephropathy (HIVAN) is a rapidly progressive kidney disease that is caused by HIV infection of renal epithelial cells with subsequent expression of viral genes, including vpr. Antiretroviral therapy ameliorates HIVAN without eradicating HIV from the kidneys and the mechan...read more

Mentioned in this Paper

Genes
Genes, Viral
Genetic Vectors
HIV
HIV Infections
2
2
Paper Details
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