PMID: 9438205Jan 23, 1998Paper

The HLA-A*0207 peptide binding repertoire is limited to a subset of the A*0201 repertoire

Human Immunology
John SidneyAlessandro Sette

Abstract

Quantitative A*0207 peptide binding assays have been developed utilizing HLA transfected cells and affinity purified molecules. By using a panel of single substitution analog peptides, it was demonstrated that A*0207 binds peptides with main anchor specificity at position 2 and the C-terminus similar to A*0201. Previous data indicating that A*0207 (but not A*0201) also requires the presence of D or P in position 3 of its peptide ligands was confirmed by the analysis of additional single substituted analogs. Finally, by analyzing the A*0201 and A*0207 binding capacities of panels of unrelated synthetic peptides, it was found that 8/15 (53.3%) A*0201 binders with D or P in position 3 bound A*0207, while only 5/72 (6.9%) A*0201 binders without D or P in position 3 also bound A*0207. Together, these data indicate that although A*0207 may be included amongst A2 supertype alleles, its peptide binding repertoire is largely limited to a subset of that bound by A*0201.

References

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Citations

Sep 2, 1998·Current Opinion in Immunology·A Sette, J Sidney
Jan 24, 2008·BMC Immunology·John SidneyAlessandro Sette
Dec 21, 2007·Journal of Pharmacological Sciences·Hiromichi Tsurui, Takuya Takahashi
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simona VertuaniRolf Kiessling
Jan 7, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael GleimerPeter Parham
Nov 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T K HoffmannA B DeLeo
Aug 10, 2021·The Journal of Biological Chemistry·Nadia AnikeevaYuri Sykulev

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