The HLA-C*06 allele as a possible genetic predisposing factor to psoriasis in South Indian Tamils

Archives of Dermatological Research
S IndhumathiVir S Negi

Abstract

Psoriasis is a multi-factorial heritable prototypical immune-mediated inflammatory disease, characterized by hyperproliferation of keratinocytes in the affected skin. There are no studies till date, to the best of our knowledge, about the association of HLA-C*06, the risk variant in the PSORS 1 susceptibility locus that confers the greatest risk for early onset of psoriasis, with the disease in South Indian Tamil patients with psoriasis. The present study was performed to determine the association of HLA-C*06 with psoriasis in the South Indian Tamil ethnic population. Three hundred and fifty-five cases of psoriasis and 360 healthy controls were included in this case-control study. Severity grading according to psoriasis area severity index (PASI) scoring was done in patients with psoriasis. PCR assays with sequence-specific primers (PCR-SSP) were used for specific detection of HLA-C*06. PCR with analysis of restriction fragment length polymorphism was used to distinguish between patients homozygous and heterozygous for HLA-C*06. We observed that those with the HLA-C*06-positive allele had a 3.5 times higher odds of having psoriasis compared to those without, [p < 0.0001, OR 3.5, 95 % CI (2.59-4.79)]. Among cases of psoriasis, i...Continue Reading

References

Aug 1, 1989·Tissue Antigens·R M PitchappanV Brahmajothibai
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Sep 1, 1996·The British Journal of Dermatology·H F GonzagaM Gerbase-Delima
Feb 14, 2002·The Journal of Investigative Dermatology·Jóhann E GudjónssonHelgi Valdimarsson
Mar 26, 2003·The British Journal of Dermatology·Y T ChangC K Wong
Dec 18, 2003·Clinical and Experimental Immunology·J E GudjonssonH Valdimarsson
Sep 25, 2004·Journal of the American Academy of Dermatology·Richard G Langley, Charles N Ellis
Apr 28, 2006·American Journal of Human Genetics·Rajan P NairJames T Elder
Jul 28, 2006·Arthritis and Rheumatism·William TaylorUNKNOWN CASPAR Study Group
Jan 17, 2007·The British Journal of Dermatology·C E M GriffithsL Fry
Feb 23, 2007·Nature·Michelle A LowesJames G Krueger
Jul 31, 2007·Lancet·Christopher Em Griffiths, Jonathan Nwn Barker
Oct 31, 2009·Clinical and Experimental Dermatology·K RebałaJ Wysocka
Nov 17, 2010·Indian Journal of Dermatology, Venereology and Leprology·Sunil Dogra, Savita Yadav
Dec 24, 2011·Genetics and Molecular Research : GMR·D WuX D Zhang
Aug 13, 2013·American Journal of Human Genetics·Priya MoorjaniLalji Singh
Aug 8, 2014·The Journal of Dermatology·Tomotaka MabuchiAkira Oka
May 8, 2015·Postgraduate Medical Journal·Dharshini SathishkumarJohn Victor Peter

❮ Previous
Next ❯

Citations

Jun 5, 2004·World Journal of Surgical Oncology·Eray CopcuNil Culhaci
Oct 27, 2017·The British Journal of Dermatology·L Chen, T-F Tsai
Dec 22, 2017·The Indian Journal of Medical Research·Devinder Mohan Thappa, Malathi Munisamy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved