The HLA-DRB1*1501 allele is prevalent among Japanese patients with anti-glomerular basement membrane antibody-mediated disease

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Wataru KitagawaSatoshi Sugiyama

Abstract

We aimed to clarify the relationship between HLA-DRB1(*)1501 and anti-glomerular basement membrane (GBM) antibody-mediated disease in Japanese patients. Samples were collected from 16 anti-GBM antibody-positive patients who were admitted to our department or related hospitals from December 1990 to October 2005. We analysed clinical and laboratory data, kidney biopsy findings, and the HLA-DR phenotypes and HLA-DRB1 alleles of the patients. Among the 16 patients, 15 had HLA-DR15 [the phenotype frequency (PF) was 93.8%], 7 were positive for DR4 (the PF was 43.8%) and 5 were positive for DR9 (the PF was 31.3%). The allele frequency of HLA-DRB1(*)1501 was 46.4% (13/28), which was significantly different from Japanese controls (11.6%) (P < 0.001). In contrast, the frequency of HLA-DRB1(*)1502 was not different from controls (0/28). The odds ratio of HLA-DRB1(*)1501 in these patients was 6.4 (95% CI: 2.4-16.5). The present study demonstrated that Japanese patients with anti-GBM antibody-mediated disease are very likely to carry the HLA-DRB1(*)1501 but not the HLA-DRB1(*)1502 allele.

References

Aug 2, 1996·The Journal of Biological Chemistry·R G PhelpsA J Rees
Apr 15, 2005·Clinical and Experimental Nephrology·Wataru KitagawaHirokazu Imai

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Citations

Jul 31, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Xu-Jie ZhouHong Zhang
Dec 3, 2010·Current Opinion in Rheumatology·Philippa Peto, Alan D Salama
Aug 24, 2010·Orphanet Journal of Rare Diseases·Annick ClementHarriet Corvol
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Aug 6, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Rui YangMing-Hui Zhao
Aug 9, 2016·Matrix Biology : Journal of the International Society for Matrix Biology·Mary H Foster
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Jul 20, 2011·Nature Reviews. Nephrology·Zhao Cui, Ming-Hui Zhao
May 19, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Stephen P McAdoo, Charles D Pusey
Oct 30, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mårten Segelmark, Thomas Hellmark
Nov 8, 2014·PloS One·Nuha Mahmoud HamdiAmr Ekhlas Eid
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Sep 30, 2020·Advances in Anatomic Pathology·Mohammed AkhtarMuhammad Asim
Nov 11, 2019·La Presse médicale·Maria Prendecki, Charles Pusey

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