PMID: 9174140May 1, 1997Paper

The HLA system in the population of Mongolia

Tissue Antigens
N O ChimgeT Juji

Abstract

The frequencies of HLA-A, B, C and DRB1 alleles and haplotype frequencies for HLA-A, B, C and A, B, DR loci were studied in 201 healthy unrelated Khalkha-Mongolians. The most common class I antigens were A24 (25.8%), A2 (23.4%), B61 (12.6%), B51 (8.5%), Cw10 (14.2%), Cw9 (14.1%), Cw7 (13.3%), Cw1 (11.8%) and Cw6 (10.2%). A total of 35 DRB1 alleles were identified in this group of samples. The most frequent DRB1 allele was DRB1*0301 (11.1%), followed by DRB1*0701 (9.7%) and DRB1*1101 (8.5%). One novel DRB1 allele (14MV) and three rare types, DRB1*1111, DRB1*1504 and DRB1*1412, recently described in Jews, the Dai minority of China and Japanese, respectively, were identified in Mongolians. The phylogenetic tree constructed by UPG method put Mongolians in the Northeast Asian cluster. A comparison of three locus haplotype distributions with world populations, revealed that Mongolians share several characteristics in common with other Mongoloids as well as with Caucasoids and Amerindians. The most common A, B and DR haplotype in Mongolians, A33-B58-DR3, was shared with Thai, Thai Chinese and Singapore Chinese. These data support that unique genetic background of Mongolians played a major role in ethnic formation and differentiation o...Continue Reading

References

Aug 22, 1973·Journal of Theoretical Biology·M Ruse
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·J V NeelR I Sukernik
Feb 1, 1994·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·M BannaiT Juji
Dec 5, 1964·Nature·P I TERASAKI, J D MCCLELLAND
Aug 1, 1991·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·W SakamotoS Tano

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Citations

Feb 11, 1998·Tissue Antigens·K KashiwaseT Juji
Sep 5, 2001·American Journal of Human Biology : the Official Journal of the Human Biology Council·Nyam-Osorin Chimge, Jamiyangiin Batsuuri
Nov 26, 2002·Tissue Antigens·A MohyuddinS Q Mehdi
May 20, 2003·Tissue Antigens·H K G MachullaM T Dorak

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