The HLH protein Extramacrochaetae is required for R7 cell and cone cell fates in the Drosophila eye.

Developmental Biology
Abhishek Bhattacharya, Nicholas E Baker

Abstract

Notch signaling is one of the most important pathways in development and homeostasis, and is altered in multiple pathologies. Study of Drosophila eye development shows that Notch signaling depends on the HLH protein Extramacrochaetae. Null mutant clones show that extramacrochaetae is required for multiple aspects of eye development that depend on Notch signaling, including morphogenetic furrow progression, differentiation of R4, R7 and cone cell types, and rotation of ommatidial clusters. Detailed analysis of R7 and cone cell specification reveals that extramacrochaetae acts cell autonomously and epistatically to Notch, and is required for normal expression of bHLH genes encoded by the E(spl)-C which are effectors of most Notch signaling. A model is proposed in which Extramacrochaetae acts in parallel to or as a feed-forward regulator of the E(spl)-Complex to promote Notch signaling in particular cellular contexts.

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Citations

Aug 31, 2011·Molecular Genetics and Genomics : MGG·Mark Charlton-PerkinsTiffany A Cook
May 24, 2011·Developmental Neurobiology·Justin P Kumar
Feb 1, 2015·Neural Development·Jennifer K FinleyTory G Herman
Jul 28, 2009·Current Biology : CB·Adam C MillerTory G Herman
Nov 15, 2011·Cell·Abhishek Bhattacharya, Nicholas E Baker
Nov 12, 2015·Developmental Cell·Lan-Hsin Wang, Nicholas E Baker
Jul 20, 2016·PLoS Genetics·Yannis Emmanuel Mavromatakis, Andrew Tomlinson
Jan 7, 2017·PloS One·Orly DorotMia Horowitz
Feb 7, 2017·Fly·Yannis Emmanuel Mavromatakis, Andrew Tomlinson
Feb 26, 2015·Development·Carrie M Spratford, Justin P Kumar
May 16, 2015·Development·Carrie M Spratford, Justin P Kumar
Aug 4, 2021·Developmental Biology·Mark A Charlton-PerkinsTiffany A Cook

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