The hOGG1 Ser326Cys polymorphism and prostate cancer risk: a meta-analysis of 2584 cases and 3234 controls.

BMC Cancer
Hongtuan ZhangLiang Li

Abstract

Genetic polymorphism of human 8-oxoguanine glycosylase 1 (hOGG1) Ser326Cys (rs1052133) has been implicated to alter the risk of prostate cancer, but the results are controversial. Two investigators independently searched the Medline, and Cochrane Library up to June 7, 2011. Summary odds ratios (OR) and 95% confidence interval (CI) for Ser326Cys polymorphism and prostate cancer were calculated. Statistical analysis was performed with the software program Review Manage, version 5.0 and Stata 10.0. A total of 8 independent studies, including 2584 cases and 3234 controls, were identified. Our analysis suggested that Ser326Cys was not associated with prostate cancer risk in overall population. In the subgroup analysis, we detected the significant association between Ser326Cys polymorphism and decreased prostate risk in mixed population under additive model (OR = 0.67, 95% CI = 0.50-0.90, P = 0.007), recessive model (OR = 0.68, 95% CI = 0.51-0.91, P = 0.008), and Cys allele versus Ser allele (OR = 0.88, 95% CI = 0.78-0.98, P = 0.02). Subanalysis on Caucasian subjects demonstrated that Ser326Cys was not associated with prostate cancer risk. This meta-analysis showed the evidence that hOGG1 Ser326Cys polymorphism was associated with a ...Continue Reading

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Citations

Mar 23, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jin HuangLiang Du
Dec 20, 2012·Antioxidants & Redox Signaling·Sarah J StorrStewart G Martin
Aug 21, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yanliang HuJinjie Zhang
Dec 10, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Huanlei WuXianglin Yuan
Jan 15, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lizhi TangYonggang Zhang
Jan 15, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Liang LiWenjing Hou
May 20, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zihan SunZhiqiang Fan
Apr 4, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Peng LiTao Hao
Jul 28, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Gloria RavegniniSabrina Angelini
Apr 25, 2015·The International Journal of Biological Markers·Yang ChenZengnan Mo

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