PMID: 16537987Mar 16, 2006Paper

The homeostasis model assessment-insulin resistance index is inversely associated with serum carotenoids in non-diabetic subjects

Journal of Epidemiology
M SugiuraAkihiko Nagao

Abstract

Carotenoids may reduce the risk for diabetes mellitus, but little is known about the association of insulin resistance with serum carotenoids in non-diabetic subjects. This study aimed to investigate whether the homeostasis model assessment-insulin resistance (HOMA-IR) index would be lower in the presence of high serum carotenoid concentrations in non-diabetic subjects. A total of 812 subjects (256 males and 556 females) who had received health examinations in 2003 participated in the study. The associations of the serum-carotenoid concentrations and HOMA-IR were evaluated cross-sectionally. The multivariate-adjusted geometric means of HOMA-IR by the tertiles of the serum carotenoid concentration were calculated after adjusting for age, body mass index, systolic blood pressure, total cholesterol, triacylglycerols, current tobacco use, regular alcohol intake, exercise habits and total energy intake. Associations among high HOMA-IR (3.0+mUxmmol/L2) across tertiles of serum carotenoid concentration were assessed by tests for logistic regression analysis. In male subjects, the multivariate adjusted geometric mean of HOMA-IR was inversely associated with the serum beta-cryptoxanthin concentrations. In female subjects, an inverse ass...Continue Reading

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Citations

Oct 19, 2006·Current Atherosclerosis Reports·Earl S Ford
Jun 17, 2008·The British Journal of Nutrition·Laima BrazionisKerin O'Dea
Jan 1, 2011·Journal of Nutritional Science and Vitaminology·Yoshiyuki ShirakuraMakoto Inoue
Mar 7, 2015·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Minoru Sugiura
Jul 19, 2014·Bioscience, Biotechnology, and Biochemistry·Minoru SugiuraMasamichi Yano
Jan 15, 2016·The American Journal of Clinical Nutrition·Elisabeth Tm LeermakersOscar H Franco
Jun 11, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Laura FranziniIvana Zavaroni
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Mar 26, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Toni A M TobiasDeepa Rastogi
Jun 12, 2020·Obesity Science & Practice·Annick V HartstraMax Nieuwdorp

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