PMID: 11337208May 5, 2001Paper

The homocysteine distribution: (mis)judging the burden

Journal of Clinical Epidemiology
Angelika de BreeDaan Kromhout

Abstract

The nonfasting plasma total homocysteine (P-tHcy) concentration was measured in a random sample of 3025 Dutch adults aged 20-65 years (main study). The positively skewed distribution had a geometric mean of 13.9 micromol/L in men and 12.6 micromol/L in women. Blood of the main study was not cooled or centrifuged immediately after drawing. A stability study (n = 26) indicated that this could have resulted in a small (0.4 micromol/L) overestimation of the means. A comparative study (n = 88), and a reproduction of these results in an entirely different population (n = 213), showed a systematic difference in P-tHcy concentration of -2.4 micromol/L between our laboratory (Nijmegen, the Netherlands) and that in Bergen, Norway. With the information of the additional studies we provided precise and valid data of the Dutch P-tHcy distribution, from which we conclude the status in the Netherlands is worse than in other European countries. Furthermore, we showed that comparison of P-tHcy data is complicated unless the interlaboratory differences are known. @ 2001 Elsevier Science Inc.

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Citations

Feb 6, 2003·Fertility and Sterility·Noha H FaragPaul J Mills
Sep 13, 2002·Thyroid : Official Journal of the American Thyroid Association·Robert Deicher, Heinrich Vierhapper
Jan 25, 2003·Journal of Internal Medicine·P R W de Sauvage NoltingJ J P Kastelein
Feb 22, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Chiaki YaguraKiyoshi Aoyagi
Jun 21, 2001·International Journal of Epidemiology·A De BreeD Kromhout
Jan 28, 2005·European Journal of Clinical Nutrition·A de BreeP M Ueland
May 27, 2003·Clinical Chemistry·Angelika de BreePilar Galan
May 11, 2005·The American Journal of Clinical Nutrition·Ingrid M van BeynumHenk J Blom
Sep 8, 2007·The American Journal of Clinical Nutrition·Angelika de BreeRichard Draijer
Aug 3, 2019·Journal of the Neurological Sciences·Yifan JiYanhong Dong

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